Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA

HIV-1 integrase (IN) has a noncatalytic function in virion maturation through its binding to the viral RNA genome (gRNA). Class II IN substitutions inhibit IN-gRNA binding and result in the formation of virions with aberrant morphologies marked by mislocalization of the gRNA between the capsid latti...

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Detalles Bibliográficos
Autores principales: Shema Mugisha, Christian, Dinh, Tung, Kumar, Abhishek, Tenneti, Kasyap, Eschbach, Jenna E., Davis, Keanu, Gifford, Robert, Kvaratskhelia, Mamuka, Kutluay, Sebla B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601147/
https://www.ncbi.nlm.nih.gov/pubmed/35975921
http://dx.doi.org/10.1128/mbio.00431-22

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