Cargando…

Diagnostic Efficacy of CT Examination on Early Detection of Lung Cancer during Pandemic of COVID-19

Background: Since the outbreak of COVID-19 in 2020, routine CT examination was recommended to hospitalized patients at some hospitals and discovered lung cancer patients at an early stage. This study aimed to investigate the detection efficacy of routine CT examination on early diagnosis of lung can...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Yanjie, Wang, Ruibin, Shi, Feng, Wu, Jiangping, Jiang, Fusheng, Song, Qingkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601167/
https://www.ncbi.nlm.nih.gov/pubmed/36292005
http://dx.doi.org/10.3390/diagnostics12102317
_version_ 1784816990598201344
author Zhao, Yanjie
Wang, Ruibin
Shi, Feng
Wu, Jiangping
Jiang, Fusheng
Song, Qingkun
author_facet Zhao, Yanjie
Wang, Ruibin
Shi, Feng
Wu, Jiangping
Jiang, Fusheng
Song, Qingkun
author_sort Zhao, Yanjie
collection PubMed
description Background: Since the outbreak of COVID-19 in 2020, routine CT examination was recommended to hospitalized patients at some hospitals and discovered lung cancer patients at an early stage. This study aimed to investigate the detection efficacy of routine CT examination on early diagnosis of lung cancer, especially on pathological characteristics. Methods: The epidemic of COVID-19 outbreak in January 2020 in China, and routine CT examination was recommended to hospitalized patients in June 2020 and ended in July 2021. Based on the time points, we compared the diagnosis efficacy between three periods: pre-period, peri-period, and the period of routine CT examination. Results: During the period of routine CT examination, more early stages of lung cancer were detected and the tumor size was reduced to 2.14 cm from 3.21 cm at pre-period (p = 0.03). The proportion of lung adenocarcinoma and early stage adenocarcinoma was increased by 12% and 30% in the period of routine CT examination, with referral to the pre-period of CT examination (p < 0.05). A total of 61% of diagnosed patients had the wild type of TP53 gene during the period of routine CT examination, compared to 45% of patients at the pre-period of CT examination (p = 0.001). The median Ki-67 index was 15% among patients diagnosed at the period of routine CT examination and increased to 35% at the pre-period of CT examination (p < 0.001). The period of routine CT examination was associated with a 78% higher probability of detecting an early stage of adenocarcinoma (OR = 1.78, 95%CI 1.03, 3.08) but no significant association was observed for squamous cell carcinoma. From the pre-period to the period of routine CT examination, the proportion of female patients and non-smoking patients increased by 57% and 44%, respectively (p < 0.001). Conclusion: Routine CT examination could detect more lung cancer at an early stage, especially for adenocarcinoma, and detect patients with less aggressive features. Further studies were warranted to confirm the findings.
format Online
Article
Text
id pubmed-9601167
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96011672022-10-27 Diagnostic Efficacy of CT Examination on Early Detection of Lung Cancer during Pandemic of COVID-19 Zhao, Yanjie Wang, Ruibin Shi, Feng Wu, Jiangping Jiang, Fusheng Song, Qingkun Diagnostics (Basel) Article Background: Since the outbreak of COVID-19 in 2020, routine CT examination was recommended to hospitalized patients at some hospitals and discovered lung cancer patients at an early stage. This study aimed to investigate the detection efficacy of routine CT examination on early diagnosis of lung cancer, especially on pathological characteristics. Methods: The epidemic of COVID-19 outbreak in January 2020 in China, and routine CT examination was recommended to hospitalized patients in June 2020 and ended in July 2021. Based on the time points, we compared the diagnosis efficacy between three periods: pre-period, peri-period, and the period of routine CT examination. Results: During the period of routine CT examination, more early stages of lung cancer were detected and the tumor size was reduced to 2.14 cm from 3.21 cm at pre-period (p = 0.03). The proportion of lung adenocarcinoma and early stage adenocarcinoma was increased by 12% and 30% in the period of routine CT examination, with referral to the pre-period of CT examination (p < 0.05). A total of 61% of diagnosed patients had the wild type of TP53 gene during the period of routine CT examination, compared to 45% of patients at the pre-period of CT examination (p = 0.001). The median Ki-67 index was 15% among patients diagnosed at the period of routine CT examination and increased to 35% at the pre-period of CT examination (p < 0.001). The period of routine CT examination was associated with a 78% higher probability of detecting an early stage of adenocarcinoma (OR = 1.78, 95%CI 1.03, 3.08) but no significant association was observed for squamous cell carcinoma. From the pre-period to the period of routine CT examination, the proportion of female patients and non-smoking patients increased by 57% and 44%, respectively (p < 0.001). Conclusion: Routine CT examination could detect more lung cancer at an early stage, especially for adenocarcinoma, and detect patients with less aggressive features. Further studies were warranted to confirm the findings. MDPI 2022-09-26 /pmc/articles/PMC9601167/ /pubmed/36292005 http://dx.doi.org/10.3390/diagnostics12102317 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhao, Yanjie
Wang, Ruibin
Shi, Feng
Wu, Jiangping
Jiang, Fusheng
Song, Qingkun
Diagnostic Efficacy of CT Examination on Early Detection of Lung Cancer during Pandemic of COVID-19
title Diagnostic Efficacy of CT Examination on Early Detection of Lung Cancer during Pandemic of COVID-19
title_full Diagnostic Efficacy of CT Examination on Early Detection of Lung Cancer during Pandemic of COVID-19
title_fullStr Diagnostic Efficacy of CT Examination on Early Detection of Lung Cancer during Pandemic of COVID-19
title_full_unstemmed Diagnostic Efficacy of CT Examination on Early Detection of Lung Cancer during Pandemic of COVID-19
title_short Diagnostic Efficacy of CT Examination on Early Detection of Lung Cancer during Pandemic of COVID-19
title_sort diagnostic efficacy of ct examination on early detection of lung cancer during pandemic of covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601167/
https://www.ncbi.nlm.nih.gov/pubmed/36292005
http://dx.doi.org/10.3390/diagnostics12102317
work_keys_str_mv AT zhaoyanjie diagnosticefficacyofctexaminationonearlydetectionoflungcancerduringpandemicofcovid19
AT wangruibin diagnosticefficacyofctexaminationonearlydetectionoflungcancerduringpandemicofcovid19
AT shifeng diagnosticefficacyofctexaminationonearlydetectionoflungcancerduringpandemicofcovid19
AT wujiangping diagnosticefficacyofctexaminationonearlydetectionoflungcancerduringpandemicofcovid19
AT jiangfusheng diagnosticefficacyofctexaminationonearlydetectionoflungcancerduringpandemicofcovid19
AT songqingkun diagnosticefficacyofctexaminationonearlydetectionoflungcancerduringpandemicofcovid19