Intracellular Metabolomics Identifies Efflux Transporter Inhibitors in a Routine Caco-2 Cell Permeability Assay—Biological Implications

Caco-2 screens are routinely used in laboratories to measure the permeability of compounds and can identify substrates of efflux transporters. In this study, we hypothesized that efflux transporter inhibition of a compound can be predicted by an intracellular metabolic signature in Caco-2 cells in t...

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Detalles Bibliográficos
Autores principales: Naseem, Afia, Pal, Akos, Gowan, Sharon, Asad, Yasmin, Donovan, Adam, Temesszentandrási-Ambrus, Csilla, Kis, Emese, Gaborik, Zsuzsanna, Bhalay, Gurdip, Raynaud, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601193/
https://www.ncbi.nlm.nih.gov/pubmed/36291153
http://dx.doi.org/10.3390/cells11203286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601193/
https://www.ncbi.nlm.nih.gov/pubmed/36291153
http://dx.doi.org/10.3390/cells11203286

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