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Differentiation of Intracerebral Tumor Entities with Quantitative Contrast Attenuation and Iodine Mapping in Dual-Layer Computed Tomography

Purpose: To investigate if quantitative contrast enhancement and iodine mapping of common brain tumor (BT) entities may correctly differentiate between tumor etiologies in standardized stereotactic CT protocols. Material and Methods: A retrospective monocentric study of 139 consecutive standardized...

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Autores principales: Borggrefe, Jan, Gebest, Max Philipp, Hauger, Myriam, Ruess, Daniel, Mpotsaris, Anastasios, Kabbasch, Christoph, Pennig, Lenhard, Laukamp, Kai Roman, Goertz, Lukas, Kroeger, Jan Robert, Doerner, Jonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601196/
https://www.ncbi.nlm.nih.gov/pubmed/36292183
http://dx.doi.org/10.3390/diagnostics12102494
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author Borggrefe, Jan
Gebest, Max Philipp
Hauger, Myriam
Ruess, Daniel
Mpotsaris, Anastasios
Kabbasch, Christoph
Pennig, Lenhard
Laukamp, Kai Roman
Goertz, Lukas
Kroeger, Jan Robert
Doerner, Jonas
author_facet Borggrefe, Jan
Gebest, Max Philipp
Hauger, Myriam
Ruess, Daniel
Mpotsaris, Anastasios
Kabbasch, Christoph
Pennig, Lenhard
Laukamp, Kai Roman
Goertz, Lukas
Kroeger, Jan Robert
Doerner, Jonas
author_sort Borggrefe, Jan
collection PubMed
description Purpose: To investigate if quantitative contrast enhancement and iodine mapping of common brain tumor (BT) entities may correctly differentiate between tumor etiologies in standardized stereotactic CT protocols. Material and Methods: A retrospective monocentric study of 139 consecutive standardized dual-layer dual-energy CT (dlDECT) scans conducted prior to the stereotactic needle biopsy of untreated primary brain tumor lesions. Attenuation of contrast-enhancing BT was derived from polyenergetic images as well as spectral iodine density maps (IDM) and their contrast-to-noise-ratios (CNR) were determined using ROI measures in contrast-enhancing BT and healthy contralateral white matter. The measures were correlated to histopathology regarding tumor entity, isocitrate dehydrogenase (IDH) and MGMT mutation status. Results: The cohort included 52 female and 76 male patients, mean age of 59.4 (±17.1) years. Brain lymphomas showed the highest attenuation (IDM CNR 3.28 ± 1,23), significantly higher than glioblastoma (2.37 ± 1.55, p < 0.005) and metastases (1.95 ± 1.14, p < 0.02), while the differences between glioblastomas and metastases were not significant. These strongly enhancing lesions differed from oligodendroglioma and astrocytoma (Grade II and III) that showed IDM CNR in the range of 1.22–1.27 (±0.45–0.82). Conventional attenuation measurements in DLCT data performed equally or slightly superior to iodine density measurements. Conclusion: Quantitative attenuation and iodine density measurements of contrast-enhancing brain tumors are feasible imaging biomarkers for the discrimination of cerebral tumor lesions but not specifically for single tumor entities. CNR based on simple HU measurements performed equally or slightly superior to iodine quantification.
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spelling pubmed-96011962022-10-27 Differentiation of Intracerebral Tumor Entities with Quantitative Contrast Attenuation and Iodine Mapping in Dual-Layer Computed Tomography Borggrefe, Jan Gebest, Max Philipp Hauger, Myriam Ruess, Daniel Mpotsaris, Anastasios Kabbasch, Christoph Pennig, Lenhard Laukamp, Kai Roman Goertz, Lukas Kroeger, Jan Robert Doerner, Jonas Diagnostics (Basel) Article Purpose: To investigate if quantitative contrast enhancement and iodine mapping of common brain tumor (BT) entities may correctly differentiate between tumor etiologies in standardized stereotactic CT protocols. Material and Methods: A retrospective monocentric study of 139 consecutive standardized dual-layer dual-energy CT (dlDECT) scans conducted prior to the stereotactic needle biopsy of untreated primary brain tumor lesions. Attenuation of contrast-enhancing BT was derived from polyenergetic images as well as spectral iodine density maps (IDM) and their contrast-to-noise-ratios (CNR) were determined using ROI measures in contrast-enhancing BT and healthy contralateral white matter. The measures were correlated to histopathology regarding tumor entity, isocitrate dehydrogenase (IDH) and MGMT mutation status. Results: The cohort included 52 female and 76 male patients, mean age of 59.4 (±17.1) years. Brain lymphomas showed the highest attenuation (IDM CNR 3.28 ± 1,23), significantly higher than glioblastoma (2.37 ± 1.55, p < 0.005) and metastases (1.95 ± 1.14, p < 0.02), while the differences between glioblastomas and metastases were not significant. These strongly enhancing lesions differed from oligodendroglioma and astrocytoma (Grade II and III) that showed IDM CNR in the range of 1.22–1.27 (±0.45–0.82). Conventional attenuation measurements in DLCT data performed equally or slightly superior to iodine density measurements. Conclusion: Quantitative attenuation and iodine density measurements of contrast-enhancing brain tumors are feasible imaging biomarkers for the discrimination of cerebral tumor lesions but not specifically for single tumor entities. CNR based on simple HU measurements performed equally or slightly superior to iodine quantification. MDPI 2022-10-15 /pmc/articles/PMC9601196/ /pubmed/36292183 http://dx.doi.org/10.3390/diagnostics12102494 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Borggrefe, Jan
Gebest, Max Philipp
Hauger, Myriam
Ruess, Daniel
Mpotsaris, Anastasios
Kabbasch, Christoph
Pennig, Lenhard
Laukamp, Kai Roman
Goertz, Lukas
Kroeger, Jan Robert
Doerner, Jonas
Differentiation of Intracerebral Tumor Entities with Quantitative Contrast Attenuation and Iodine Mapping in Dual-Layer Computed Tomography
title Differentiation of Intracerebral Tumor Entities with Quantitative Contrast Attenuation and Iodine Mapping in Dual-Layer Computed Tomography
title_full Differentiation of Intracerebral Tumor Entities with Quantitative Contrast Attenuation and Iodine Mapping in Dual-Layer Computed Tomography
title_fullStr Differentiation of Intracerebral Tumor Entities with Quantitative Contrast Attenuation and Iodine Mapping in Dual-Layer Computed Tomography
title_full_unstemmed Differentiation of Intracerebral Tumor Entities with Quantitative Contrast Attenuation and Iodine Mapping in Dual-Layer Computed Tomography
title_short Differentiation of Intracerebral Tumor Entities with Quantitative Contrast Attenuation and Iodine Mapping in Dual-Layer Computed Tomography
title_sort differentiation of intracerebral tumor entities with quantitative contrast attenuation and iodine mapping in dual-layer computed tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601196/
https://www.ncbi.nlm.nih.gov/pubmed/36292183
http://dx.doi.org/10.3390/diagnostics12102494
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