Activation of PPARα Ameliorates Cardiac Fibrosis in Dsg2-Deficient Arrhythmogenic Cardiomyopathy

HIGHLIGHTS: Cardiac-specific Dsg2 deletion induces excessive cardiac fibrosis in mice. Fenofibrate alleviates cardiac fibrosis in CS-Dsg2(−/−) mice. Cardiac-specific activation of PPARα ameliorates cardiac fibrosis in CS-Dsg2(−/−) mice. The inhibitory effect of PPARα on cardiac fibrosis is mediated...

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Detalles Bibliográficos
Autores principales: Qiu, Zirui, Zhao, Yawen, Tao, Tian, Guo, Wenying, Liu, Ruonan, Huang, Jingmin, Xu, Geyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601208/
https://www.ncbi.nlm.nih.gov/pubmed/36291052
http://dx.doi.org/10.3390/cells11203184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601208/
https://www.ncbi.nlm.nih.gov/pubmed/36291052
http://dx.doi.org/10.3390/cells11203184

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