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Activation of PPARα Ameliorates Cardiac Fibrosis in Dsg2-Deficient Arrhythmogenic Cardiomyopathy
HIGHLIGHTS: Cardiac-specific Dsg2 deletion induces excessive cardiac fibrosis in mice. Fenofibrate alleviates cardiac fibrosis in CS-Dsg2(−/−) mice. Cardiac-specific activation of PPARα ameliorates cardiac fibrosis in CS-Dsg2(−/−) mice. The inhibitory effect of PPARα on cardiac fibrosis is mediated...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601208/ https://www.ncbi.nlm.nih.gov/pubmed/36291052 http://dx.doi.org/10.3390/cells11203184 |