Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures

Angiotensin IV (Ang IV), a metabolite of Angiotensin II, is a bioactive hexapeptide that inhibits the insulin-regulated aminopeptidase (IRAP). This transmembrane zinc metallopeptidase with many biological functions has in recent years emerged as a new pharmacological target. IRAP is expressed in a v...

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Detalles Bibliográficos
Autores principales: Stam, Frida, Florén Lind, Sara, Schroff, Anja, Zelleroth, Sofia, Nylander, Erik, Gising, Johan, Grönbladh, Alfhild, Larhed, Mats, Hallberg, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601255/
https://www.ncbi.nlm.nih.gov/pubmed/36286055
http://dx.doi.org/10.3390/cimb44100340

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