Cargando…

Dietary Interventions of Salmon and Silver Carp Phospholipids on Mice with Metabolic Syndrome Based on Lipidomics

The number of metabolic syndromes (MetS) is increasing, and a fish phospholipid diet can reduce the risk of MetS. In this study, the changes in lipid metabolism of colon contents were analyzed by extensive lipidomics in mice with metabolic syndrome by fish phospholipid diet, and mice were randomly d...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Hongbiao, Li, Yun, Yi, Ping, Cao, Hui, Wang, Qi, Zhao, Xiuju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601277/
https://www.ncbi.nlm.nih.gov/pubmed/36291067
http://dx.doi.org/10.3390/cells11203199
_version_ 1784817021369712640
author Chen, Hongbiao
Li, Yun
Yi, Ping
Cao, Hui
Wang, Qi
Zhao, Xiuju
author_facet Chen, Hongbiao
Li, Yun
Yi, Ping
Cao, Hui
Wang, Qi
Zhao, Xiuju
author_sort Chen, Hongbiao
collection PubMed
description The number of metabolic syndromes (MetS) is increasing, and a fish phospholipid diet can reduce the risk of MetS. In this study, the changes in lipid metabolism of colon contents were analyzed by extensive lipidomics in mice with metabolic syndrome by fish phospholipid diet, and mice were randomly divided into experimental groups with different diet types by establishing a MetS model. After 14 weeks, the mice were sacrificed and the serum and colon contents were collected. Ultra-high liquid phase tandem mass spectrometry was used for broadly targeted lipidomic analysis, and the qualitative and quantitative detection of lipid metabolism changes in the colonic contents of mice. Under the intervention of fish phospholipids, MetS mice were significantly inhibited, serum total cholesterol (TC) and triglycerides (TG) decreased, serum high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) levels were improved, fasting blood glucose and insulin levels decreased, and inflammatory factors decreased. Through screening, it was found that thirty-three lipid metabolites may be key metabolites and five have significantly changed metabolic pathways. Modularizing lipid metabolites, it is possible to understand the extent to which different types and concentrations of fish phospholipids affect metabolic syndrome. Therefore, our study may provide new therapeutic clues for improving MetS.
format Online
Article
Text
id pubmed-9601277
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96012772022-10-27 Dietary Interventions of Salmon and Silver Carp Phospholipids on Mice with Metabolic Syndrome Based on Lipidomics Chen, Hongbiao Li, Yun Yi, Ping Cao, Hui Wang, Qi Zhao, Xiuju Cells Article The number of metabolic syndromes (MetS) is increasing, and a fish phospholipid diet can reduce the risk of MetS. In this study, the changes in lipid metabolism of colon contents were analyzed by extensive lipidomics in mice with metabolic syndrome by fish phospholipid diet, and mice were randomly divided into experimental groups with different diet types by establishing a MetS model. After 14 weeks, the mice were sacrificed and the serum and colon contents were collected. Ultra-high liquid phase tandem mass spectrometry was used for broadly targeted lipidomic analysis, and the qualitative and quantitative detection of lipid metabolism changes in the colonic contents of mice. Under the intervention of fish phospholipids, MetS mice were significantly inhibited, serum total cholesterol (TC) and triglycerides (TG) decreased, serum high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) levels were improved, fasting blood glucose and insulin levels decreased, and inflammatory factors decreased. Through screening, it was found that thirty-three lipid metabolites may be key metabolites and five have significantly changed metabolic pathways. Modularizing lipid metabolites, it is possible to understand the extent to which different types and concentrations of fish phospholipids affect metabolic syndrome. Therefore, our study may provide new therapeutic clues for improving MetS. MDPI 2022-10-12 /pmc/articles/PMC9601277/ /pubmed/36291067 http://dx.doi.org/10.3390/cells11203199 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Hongbiao
Li, Yun
Yi, Ping
Cao, Hui
Wang, Qi
Zhao, Xiuju
Dietary Interventions of Salmon and Silver Carp Phospholipids on Mice with Metabolic Syndrome Based on Lipidomics
title Dietary Interventions of Salmon and Silver Carp Phospholipids on Mice with Metabolic Syndrome Based on Lipidomics
title_full Dietary Interventions of Salmon and Silver Carp Phospholipids on Mice with Metabolic Syndrome Based on Lipidomics
title_fullStr Dietary Interventions of Salmon and Silver Carp Phospholipids on Mice with Metabolic Syndrome Based on Lipidomics
title_full_unstemmed Dietary Interventions of Salmon and Silver Carp Phospholipids on Mice with Metabolic Syndrome Based on Lipidomics
title_short Dietary Interventions of Salmon and Silver Carp Phospholipids on Mice with Metabolic Syndrome Based on Lipidomics
title_sort dietary interventions of salmon and silver carp phospholipids on mice with metabolic syndrome based on lipidomics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601277/
https://www.ncbi.nlm.nih.gov/pubmed/36291067
http://dx.doi.org/10.3390/cells11203199
work_keys_str_mv AT chenhongbiao dietaryinterventionsofsalmonandsilvercarpphospholipidsonmicewithmetabolicsyndromebasedonlipidomics
AT liyun dietaryinterventionsofsalmonandsilvercarpphospholipidsonmicewithmetabolicsyndromebasedonlipidomics
AT yiping dietaryinterventionsofsalmonandsilvercarpphospholipidsonmicewithmetabolicsyndromebasedonlipidomics
AT caohui dietaryinterventionsofsalmonandsilvercarpphospholipidsonmicewithmetabolicsyndromebasedonlipidomics
AT wangqi dietaryinterventionsofsalmonandsilvercarpphospholipidsonmicewithmetabolicsyndromebasedonlipidomics
AT zhaoxiuju dietaryinterventionsofsalmonandsilvercarpphospholipidsonmicewithmetabolicsyndromebasedonlipidomics