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Antifungal Potential of Some Herb Decoctions and Essential Oils on Candida Species

(1) Background: Candidiasis is a fungal infectious disease caused by opportunistic Candida species. The incidence of candidiasis has improved, due to prolonged antibiotic therapy and an increased number of immunocompromised patients. The purpose of this study was to evaluate if decoctions and essent...

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Autores principales: Noites, Alexandra, Araújo, Bruno, Machado, Jorge, Pinto, Eugénia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601325/
https://www.ncbi.nlm.nih.gov/pubmed/36292266
http://dx.doi.org/10.3390/healthcare10101820
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author Noites, Alexandra
Araújo, Bruno
Machado, Jorge
Pinto, Eugénia
author_facet Noites, Alexandra
Araújo, Bruno
Machado, Jorge
Pinto, Eugénia
author_sort Noites, Alexandra
collection PubMed
description (1) Background: Candidiasis is a fungal infectious disease caused by opportunistic Candida species. The incidence of candidiasis has improved, due to prolonged antibiotic therapy and an increased number of immunocompromised patients. The purpose of this study was to evaluate if decoctions and essential oil (EO) of neem (Azadirachta indica, Meliaceae family), coptidis (Coptis chinensis, Ranunculaceae family), magnolia (Magnolia officinalis, Magnoliaceae family), scutellaria (Scutellaria barbata, Lamiaceae family), and the EO of manuka (Leptospermum scoparium, Myrtaceae family), have antifungal activity in vitro against some clinically prevalent species of Candida. (2) Methods: The antifungal activity was studied by the determination of the minimum inhibitory concentration (MIC) and minimum lethal concentration (MLC) against five Candida strains. The effect in dimorphic transition of Candida albicans was also evaluated for the two plants with higher antimicrobial behavior. (3) Results: C. chinensis decoction and EO and L. scoparium EO exhibited antifungal activity in Candida spp. In addition to the fact that both C. chinensis decoction and EO proved strong antifungal activity, L. scoparium EO also displayed a relevant inhibitory effect on the dimorphic transition. (4) Conclusions: The results provided support for the potential use of C. chinensis and L. scoparium in the treatment of infections by Candida spp.
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spelling pubmed-96013252022-10-27 Antifungal Potential of Some Herb Decoctions and Essential Oils on Candida Species Noites, Alexandra Araújo, Bruno Machado, Jorge Pinto, Eugénia Healthcare (Basel) Article (1) Background: Candidiasis is a fungal infectious disease caused by opportunistic Candida species. The incidence of candidiasis has improved, due to prolonged antibiotic therapy and an increased number of immunocompromised patients. The purpose of this study was to evaluate if decoctions and essential oil (EO) of neem (Azadirachta indica, Meliaceae family), coptidis (Coptis chinensis, Ranunculaceae family), magnolia (Magnolia officinalis, Magnoliaceae family), scutellaria (Scutellaria barbata, Lamiaceae family), and the EO of manuka (Leptospermum scoparium, Myrtaceae family), have antifungal activity in vitro against some clinically prevalent species of Candida. (2) Methods: The antifungal activity was studied by the determination of the minimum inhibitory concentration (MIC) and minimum lethal concentration (MLC) against five Candida strains. The effect in dimorphic transition of Candida albicans was also evaluated for the two plants with higher antimicrobial behavior. (3) Results: C. chinensis decoction and EO and L. scoparium EO exhibited antifungal activity in Candida spp. In addition to the fact that both C. chinensis decoction and EO proved strong antifungal activity, L. scoparium EO also displayed a relevant inhibitory effect on the dimorphic transition. (4) Conclusions: The results provided support for the potential use of C. chinensis and L. scoparium in the treatment of infections by Candida spp. MDPI 2022-09-21 /pmc/articles/PMC9601325/ /pubmed/36292266 http://dx.doi.org/10.3390/healthcare10101820 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Noites, Alexandra
Araújo, Bruno
Machado, Jorge
Pinto, Eugénia
Antifungal Potential of Some Herb Decoctions and Essential Oils on Candida Species
title Antifungal Potential of Some Herb Decoctions and Essential Oils on Candida Species
title_full Antifungal Potential of Some Herb Decoctions and Essential Oils on Candida Species
title_fullStr Antifungal Potential of Some Herb Decoctions and Essential Oils on Candida Species
title_full_unstemmed Antifungal Potential of Some Herb Decoctions and Essential Oils on Candida Species
title_short Antifungal Potential of Some Herb Decoctions and Essential Oils on Candida Species
title_sort antifungal potential of some herb decoctions and essential oils on candida species
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601325/
https://www.ncbi.nlm.nih.gov/pubmed/36292266
http://dx.doi.org/10.3390/healthcare10101820
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