Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population

(1) Background: Insertion-deletion (InDel) markers show the advantages of both short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) and are considered alternative markers in forensic genetics. (2) Methods: Allelic frequencies and corresponding forensic efficiency parameters of 30 a...

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Detalles Bibliográficos
Autores principales: Abreu-Glowacka, Monica, Pepinski, Witold, Michalak, Eliza, Konarzewska, Magdalena, Zak, Krzysztof, Skawronska, Malgorzata, Niemcunowicz-Janica, Anna, Soltyszewski, Ireneusz, Krajewski, Pawel, Zaba, Czeslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601377/
https://www.ncbi.nlm.nih.gov/pubmed/36292568
http://dx.doi.org/10.3390/genes13101683
Descripción
Sumario:(1) Background: Insertion-deletion (InDel) markers show the advantages of both short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) and are considered alternative markers in forensic genetics. (2) Methods: Allelic frequencies and corresponding forensic efficiency parameters of 30 autosomal polymorphic InDel loci included in the Investigator DIPplex kit (Qiagen) were obtained in a sample of 631 unrelated Polish individuals. Allelic frequency data were compared with those reported for selected populations (3) Results: All the loci conformed with Hardy-Weinberg equilibrium after applying a Bonferroni correction and no pair-wise significant linkage disequilibrium was detected. (4) Conclusions: DIPplex Kit differences were high among populations worldwide. The InDel markers are highly discriminating for human identification purposes in the Polish population.

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