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Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population

(1) Background: Insertion-deletion (InDel) markers show the advantages of both short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) and are considered alternative markers in forensic genetics. (2) Methods: Allelic frequencies and corresponding forensic efficiency parameters of 30 a...

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Autores principales: Abreu-Glowacka, Monica, Pepinski, Witold, Michalak, Eliza, Konarzewska, Magdalena, Zak, Krzysztof, Skawronska, Malgorzata, Niemcunowicz-Janica, Anna, Soltyszewski, Ireneusz, Krajewski, Pawel, Zaba, Czeslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601377/
https://www.ncbi.nlm.nih.gov/pubmed/36292568
http://dx.doi.org/10.3390/genes13101683
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author Abreu-Glowacka, Monica
Pepinski, Witold
Michalak, Eliza
Konarzewska, Magdalena
Zak, Krzysztof
Skawronska, Malgorzata
Niemcunowicz-Janica, Anna
Soltyszewski, Ireneusz
Krajewski, Pawel
Zaba, Czeslaw
author_facet Abreu-Glowacka, Monica
Pepinski, Witold
Michalak, Eliza
Konarzewska, Magdalena
Zak, Krzysztof
Skawronska, Malgorzata
Niemcunowicz-Janica, Anna
Soltyszewski, Ireneusz
Krajewski, Pawel
Zaba, Czeslaw
author_sort Abreu-Glowacka, Monica
collection PubMed
description (1) Background: Insertion-deletion (InDel) markers show the advantages of both short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) and are considered alternative markers in forensic genetics. (2) Methods: Allelic frequencies and corresponding forensic efficiency parameters of 30 autosomal polymorphic InDel loci included in the Investigator DIPplex kit (Qiagen) were obtained in a sample of 631 unrelated Polish individuals. Allelic frequency data were compared with those reported for selected populations (3) Results: All the loci conformed with Hardy-Weinberg equilibrium after applying a Bonferroni correction and no pair-wise significant linkage disequilibrium was detected. (4) Conclusions: DIPplex Kit differences were high among populations worldwide. The InDel markers are highly discriminating for human identification purposes in the Polish population.
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spelling pubmed-96013772022-10-27 Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population Abreu-Glowacka, Monica Pepinski, Witold Michalak, Eliza Konarzewska, Magdalena Zak, Krzysztof Skawronska, Malgorzata Niemcunowicz-Janica, Anna Soltyszewski, Ireneusz Krajewski, Pawel Zaba, Czeslaw Genes (Basel) Article (1) Background: Insertion-deletion (InDel) markers show the advantages of both short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) and are considered alternative markers in forensic genetics. (2) Methods: Allelic frequencies and corresponding forensic efficiency parameters of 30 autosomal polymorphic InDel loci included in the Investigator DIPplex kit (Qiagen) were obtained in a sample of 631 unrelated Polish individuals. Allelic frequency data were compared with those reported for selected populations (3) Results: All the loci conformed with Hardy-Weinberg equilibrium after applying a Bonferroni correction and no pair-wise significant linkage disequilibrium was detected. (4) Conclusions: DIPplex Kit differences were high among populations worldwide. The InDel markers are highly discriminating for human identification purposes in the Polish population. MDPI 2022-09-20 /pmc/articles/PMC9601377/ /pubmed/36292568 http://dx.doi.org/10.3390/genes13101683 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abreu-Glowacka, Monica
Pepinski, Witold
Michalak, Eliza
Konarzewska, Magdalena
Zak, Krzysztof
Skawronska, Malgorzata
Niemcunowicz-Janica, Anna
Soltyszewski, Ireneusz
Krajewski, Pawel
Zaba, Czeslaw
Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population
title Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population
title_full Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population
title_fullStr Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population
title_full_unstemmed Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population
title_short Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population
title_sort population genetic data of 30 insertion-deletion markers in the polish population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601377/
https://www.ncbi.nlm.nih.gov/pubmed/36292568
http://dx.doi.org/10.3390/genes13101683
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