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Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population
(1) Background: Insertion-deletion (InDel) markers show the advantages of both short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) and are considered alternative markers in forensic genetics. (2) Methods: Allelic frequencies and corresponding forensic efficiency parameters of 30 a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601377/ https://www.ncbi.nlm.nih.gov/pubmed/36292568 http://dx.doi.org/10.3390/genes13101683 |
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author | Abreu-Glowacka, Monica Pepinski, Witold Michalak, Eliza Konarzewska, Magdalena Zak, Krzysztof Skawronska, Malgorzata Niemcunowicz-Janica, Anna Soltyszewski, Ireneusz Krajewski, Pawel Zaba, Czeslaw |
author_facet | Abreu-Glowacka, Monica Pepinski, Witold Michalak, Eliza Konarzewska, Magdalena Zak, Krzysztof Skawronska, Malgorzata Niemcunowicz-Janica, Anna Soltyszewski, Ireneusz Krajewski, Pawel Zaba, Czeslaw |
author_sort | Abreu-Glowacka, Monica |
collection | PubMed |
description | (1) Background: Insertion-deletion (InDel) markers show the advantages of both short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) and are considered alternative markers in forensic genetics. (2) Methods: Allelic frequencies and corresponding forensic efficiency parameters of 30 autosomal polymorphic InDel loci included in the Investigator DIPplex kit (Qiagen) were obtained in a sample of 631 unrelated Polish individuals. Allelic frequency data were compared with those reported for selected populations (3) Results: All the loci conformed with Hardy-Weinberg equilibrium after applying a Bonferroni correction and no pair-wise significant linkage disequilibrium was detected. (4) Conclusions: DIPplex Kit differences were high among populations worldwide. The InDel markers are highly discriminating for human identification purposes in the Polish population. |
format | Online Article Text |
id | pubmed-9601377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96013772022-10-27 Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population Abreu-Glowacka, Monica Pepinski, Witold Michalak, Eliza Konarzewska, Magdalena Zak, Krzysztof Skawronska, Malgorzata Niemcunowicz-Janica, Anna Soltyszewski, Ireneusz Krajewski, Pawel Zaba, Czeslaw Genes (Basel) Article (1) Background: Insertion-deletion (InDel) markers show the advantages of both short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) and are considered alternative markers in forensic genetics. (2) Methods: Allelic frequencies and corresponding forensic efficiency parameters of 30 autosomal polymorphic InDel loci included in the Investigator DIPplex kit (Qiagen) were obtained in a sample of 631 unrelated Polish individuals. Allelic frequency data were compared with those reported for selected populations (3) Results: All the loci conformed with Hardy-Weinberg equilibrium after applying a Bonferroni correction and no pair-wise significant linkage disequilibrium was detected. (4) Conclusions: DIPplex Kit differences were high among populations worldwide. The InDel markers are highly discriminating for human identification purposes in the Polish population. MDPI 2022-09-20 /pmc/articles/PMC9601377/ /pubmed/36292568 http://dx.doi.org/10.3390/genes13101683 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Abreu-Glowacka, Monica Pepinski, Witold Michalak, Eliza Konarzewska, Magdalena Zak, Krzysztof Skawronska, Malgorzata Niemcunowicz-Janica, Anna Soltyszewski, Ireneusz Krajewski, Pawel Zaba, Czeslaw Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population |
title | Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population |
title_full | Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population |
title_fullStr | Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population |
title_full_unstemmed | Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population |
title_short | Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population |
title_sort | population genetic data of 30 insertion-deletion markers in the polish population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601377/ https://www.ncbi.nlm.nih.gov/pubmed/36292568 http://dx.doi.org/10.3390/genes13101683 |
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