Automated stopped-flow library synthesis for rapid optimisation and machine learning directed experimentation

For the discovery of new candidate molecules in the pharmaceutical industry, library synthesis is a critical step, in which library size, diversity, and time to synthesise are fundamental. In this work we propose stopped-flow synthesis as an intermediate alternative to traditional batch and flow che...

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Detalles Bibliográficos
Autores principales: Avila, Claudio, Cassani, Carlo, Kogej, Thierry, Mazuela, Javier, Sarda, Sunil, Clayton, Adam D., Kossenjans, Michael, Green, Clive P., Bourne, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601405/
https://www.ncbi.nlm.nih.gov/pubmed/36349112
http://dx.doi.org/10.1039/d2sc03016k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601405/
https://www.ncbi.nlm.nih.gov/pubmed/36349112
http://dx.doi.org/10.1039/d2sc03016k

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