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Probing the effect of NEK7 and cofactor interactions on dynamics of NLRP3 monomer using molecular simulation

The NLRP3 inflammasome is a cytoplasmic complex that regulates the activation of inflammatory cytokines and, given its implication in a range of diseases, is an important therapeutic target. The cofactor ATP and the centrosomal kinase NEK7 are important for NLRP3 activation. Here we have constructed...

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Detalles Bibliográficos
Autores principales: El‐Sayed, Sherihan, Freeman, Sally, Bryce, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601872/
https://www.ncbi.nlm.nih.gov/pubmed/36173167
http://dx.doi.org/10.1002/pro.4420