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Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering
Hydrogels have been extensively used as scaffolds in tissue engineering for cell adhesion, proliferation, migration, and differentiation because of their high-water content and biocompatibility similarity to the extracellular matrix. However, submicron or nanosized pore networks within hydrogels sev...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601978/ https://www.ncbi.nlm.nih.gov/pubmed/36286107 http://dx.doi.org/10.3390/gels8100606 |
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author | Ma, Yuan Wang, Xinhui Su, Ting Lu, Feng Chang, Qiang Gao, Jianhua |
author_facet | Ma, Yuan Wang, Xinhui Su, Ting Lu, Feng Chang, Qiang Gao, Jianhua |
author_sort | Ma, Yuan |
collection | PubMed |
description | Hydrogels have been extensively used as scaffolds in tissue engineering for cell adhesion, proliferation, migration, and differentiation because of their high-water content and biocompatibility similarity to the extracellular matrix. However, submicron or nanosized pore networks within hydrogels severely limit cell survival and tissue regeneration. In recent years, the application of macroporous hydrogels in tissue engineering has received considerable attention. The macroporous structure not only facilitates nutrient transportation and metabolite discharge but also provides more space for cell behavior and tissue formation. Several strategies for creating and functionalizing macroporous hydrogels have been reported. This review began with an overview of the advantages and challenges of macroporous hydrogels in the regulation of cellular behavior. In addition, advanced methods for the preparation of macroporous hydrogels to modulate cellular behavior were discussed. Finally, future research in related fields was discussed. |
format | Online Article Text |
id | pubmed-9601978 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96019782022-10-27 Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering Ma, Yuan Wang, Xinhui Su, Ting Lu, Feng Chang, Qiang Gao, Jianhua Gels Review Hydrogels have been extensively used as scaffolds in tissue engineering for cell adhesion, proliferation, migration, and differentiation because of their high-water content and biocompatibility similarity to the extracellular matrix. However, submicron or nanosized pore networks within hydrogels severely limit cell survival and tissue regeneration. In recent years, the application of macroporous hydrogels in tissue engineering has received considerable attention. The macroporous structure not only facilitates nutrient transportation and metabolite discharge but also provides more space for cell behavior and tissue formation. Several strategies for creating and functionalizing macroporous hydrogels have been reported. This review began with an overview of the advantages and challenges of macroporous hydrogels in the regulation of cellular behavior. In addition, advanced methods for the preparation of macroporous hydrogels to modulate cellular behavior were discussed. Finally, future research in related fields was discussed. MDPI 2022-09-21 /pmc/articles/PMC9601978/ /pubmed/36286107 http://dx.doi.org/10.3390/gels8100606 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ma, Yuan Wang, Xinhui Su, Ting Lu, Feng Chang, Qiang Gao, Jianhua Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering |
title | Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering |
title_full | Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering |
title_fullStr | Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering |
title_full_unstemmed | Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering |
title_short | Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering |
title_sort | recent advances in macroporous hydrogels for cell behavior and tissue engineering |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601978/ https://www.ncbi.nlm.nih.gov/pubmed/36286107 http://dx.doi.org/10.3390/gels8100606 |
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