Cargando…

Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering

Hydrogels have been extensively used as scaffolds in tissue engineering for cell adhesion, proliferation, migration, and differentiation because of their high-water content and biocompatibility similarity to the extracellular matrix. However, submicron or nanosized pore networks within hydrogels sev...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Yuan, Wang, Xinhui, Su, Ting, Lu, Feng, Chang, Qiang, Gao, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601978/
https://www.ncbi.nlm.nih.gov/pubmed/36286107
http://dx.doi.org/10.3390/gels8100606
_version_ 1784817198549696512
author Ma, Yuan
Wang, Xinhui
Su, Ting
Lu, Feng
Chang, Qiang
Gao, Jianhua
author_facet Ma, Yuan
Wang, Xinhui
Su, Ting
Lu, Feng
Chang, Qiang
Gao, Jianhua
author_sort Ma, Yuan
collection PubMed
description Hydrogels have been extensively used as scaffolds in tissue engineering for cell adhesion, proliferation, migration, and differentiation because of their high-water content and biocompatibility similarity to the extracellular matrix. However, submicron or nanosized pore networks within hydrogels severely limit cell survival and tissue regeneration. In recent years, the application of macroporous hydrogels in tissue engineering has received considerable attention. The macroporous structure not only facilitates nutrient transportation and metabolite discharge but also provides more space for cell behavior and tissue formation. Several strategies for creating and functionalizing macroporous hydrogels have been reported. This review began with an overview of the advantages and challenges of macroporous hydrogels in the regulation of cellular behavior. In addition, advanced methods for the preparation of macroporous hydrogels to modulate cellular behavior were discussed. Finally, future research in related fields was discussed.
format Online
Article
Text
id pubmed-9601978
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96019782022-10-27 Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering Ma, Yuan Wang, Xinhui Su, Ting Lu, Feng Chang, Qiang Gao, Jianhua Gels Review Hydrogels have been extensively used as scaffolds in tissue engineering for cell adhesion, proliferation, migration, and differentiation because of their high-water content and biocompatibility similarity to the extracellular matrix. However, submicron or nanosized pore networks within hydrogels severely limit cell survival and tissue regeneration. In recent years, the application of macroporous hydrogels in tissue engineering has received considerable attention. The macroporous structure not only facilitates nutrient transportation and metabolite discharge but also provides more space for cell behavior and tissue formation. Several strategies for creating and functionalizing macroporous hydrogels have been reported. This review began with an overview of the advantages and challenges of macroporous hydrogels in the regulation of cellular behavior. In addition, advanced methods for the preparation of macroporous hydrogels to modulate cellular behavior were discussed. Finally, future research in related fields was discussed. MDPI 2022-09-21 /pmc/articles/PMC9601978/ /pubmed/36286107 http://dx.doi.org/10.3390/gels8100606 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ma, Yuan
Wang, Xinhui
Su, Ting
Lu, Feng
Chang, Qiang
Gao, Jianhua
Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering
title Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering
title_full Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering
title_fullStr Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering
title_full_unstemmed Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering
title_short Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering
title_sort recent advances in macroporous hydrogels for cell behavior and tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601978/
https://www.ncbi.nlm.nih.gov/pubmed/36286107
http://dx.doi.org/10.3390/gels8100606
work_keys_str_mv AT mayuan recentadvancesinmacroporoushydrogelsforcellbehaviorandtissueengineering
AT wangxinhui recentadvancesinmacroporoushydrogelsforcellbehaviorandtissueengineering
AT suting recentadvancesinmacroporoushydrogelsforcellbehaviorandtissueengineering
AT lufeng recentadvancesinmacroporoushydrogelsforcellbehaviorandtissueengineering
AT changqiang recentadvancesinmacroporoushydrogelsforcellbehaviorandtissueengineering
AT gaojianhua recentadvancesinmacroporoushydrogelsforcellbehaviorandtissueengineering