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A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix

A suite of four drug deliverance formulations grounded on 5-fluorouracil enclosed in a chitosan-founded intercellular substance was produced by 3,7-dimethyl-2,6-octadienal with in situ hydrogelation. The formulations have been examined from a morphological and structural point of view by Fourier tra...

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Autores principales: Paun, Maria-Alexandra, Paun, Vladimir-Alexandru, Paun, Viorel-Puiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602036/
https://www.ncbi.nlm.nih.gov/pubmed/36286162
http://dx.doi.org/10.3390/gels8100661
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author Paun, Maria-Alexandra
Paun, Vladimir-Alexandru
Paun, Viorel-Puiu
author_facet Paun, Maria-Alexandra
Paun, Vladimir-Alexandru
Paun, Viorel-Puiu
author_sort Paun, Maria-Alexandra
collection PubMed
description A suite of four drug deliverance formulations grounded on 5-fluorouracil enclosed in a chitosan-founded intercellular substance was produced by 3,7-dimethyl-2,6-octadienal with in situ hydrogelation. The formulations have been examined from a morphological and structural point of view by Fourier transform infrared (FTIR) spectroscopy and microscopy with polarized light, respectively. The polarized optical microscopy (POM) pictures of the three representative formulations obtained were investigated by fractal analysis. The fractal dimension and lacunarity of each of them were thus calculated. In this paper, a novel theoretical method for mathematically describing medicament deliverance dynamics in the context of the polymeric medicament constitution limit has been advanced. Assuming that the polymeric drug motion unfolds only on the so-called non-differentiable curves (considered mathematically multifractal curves), it looks like in a one-dimensional hydrodynamic movement within a multifractal formalism, the drug-release physics models are provided by isochronous kinetics, but at a scale of resolution necessarily non-differentiable.
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spelling pubmed-96020362022-10-27 A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix Paun, Maria-Alexandra Paun, Vladimir-Alexandru Paun, Viorel-Puiu Gels Article A suite of four drug deliverance formulations grounded on 5-fluorouracil enclosed in a chitosan-founded intercellular substance was produced by 3,7-dimethyl-2,6-octadienal with in situ hydrogelation. The formulations have been examined from a morphological and structural point of view by Fourier transform infrared (FTIR) spectroscopy and microscopy with polarized light, respectively. The polarized optical microscopy (POM) pictures of the three representative formulations obtained were investigated by fractal analysis. The fractal dimension and lacunarity of each of them were thus calculated. In this paper, a novel theoretical method for mathematically describing medicament deliverance dynamics in the context of the polymeric medicament constitution limit has been advanced. Assuming that the polymeric drug motion unfolds only on the so-called non-differentiable curves (considered mathematically multifractal curves), it looks like in a one-dimensional hydrodynamic movement within a multifractal formalism, the drug-release physics models are provided by isochronous kinetics, but at a scale of resolution necessarily non-differentiable. MDPI 2022-10-16 /pmc/articles/PMC9602036/ /pubmed/36286162 http://dx.doi.org/10.3390/gels8100661 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Paun, Maria-Alexandra
Paun, Vladimir-Alexandru
Paun, Viorel-Puiu
A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix
title A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix
title_full A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix
title_fullStr A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix
title_full_unstemmed A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix
title_short A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix
title_sort multifractal vision of 5-fluorouracil release from chitosan-based matrix
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602036/
https://www.ncbi.nlm.nih.gov/pubmed/36286162
http://dx.doi.org/10.3390/gels8100661
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