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A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix
A suite of four drug deliverance formulations grounded on 5-fluorouracil enclosed in a chitosan-founded intercellular substance was produced by 3,7-dimethyl-2,6-octadienal with in situ hydrogelation. The formulations have been examined from a morphological and structural point of view by Fourier tra...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602036/ https://www.ncbi.nlm.nih.gov/pubmed/36286162 http://dx.doi.org/10.3390/gels8100661 |
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author | Paun, Maria-Alexandra Paun, Vladimir-Alexandru Paun, Viorel-Puiu |
author_facet | Paun, Maria-Alexandra Paun, Vladimir-Alexandru Paun, Viorel-Puiu |
author_sort | Paun, Maria-Alexandra |
collection | PubMed |
description | A suite of four drug deliverance formulations grounded on 5-fluorouracil enclosed in a chitosan-founded intercellular substance was produced by 3,7-dimethyl-2,6-octadienal with in situ hydrogelation. The formulations have been examined from a morphological and structural point of view by Fourier transform infrared (FTIR) spectroscopy and microscopy with polarized light, respectively. The polarized optical microscopy (POM) pictures of the three representative formulations obtained were investigated by fractal analysis. The fractal dimension and lacunarity of each of them were thus calculated. In this paper, a novel theoretical method for mathematically describing medicament deliverance dynamics in the context of the polymeric medicament constitution limit has been advanced. Assuming that the polymeric drug motion unfolds only on the so-called non-differentiable curves (considered mathematically multifractal curves), it looks like in a one-dimensional hydrodynamic movement within a multifractal formalism, the drug-release physics models are provided by isochronous kinetics, but at a scale of resolution necessarily non-differentiable. |
format | Online Article Text |
id | pubmed-9602036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96020362022-10-27 A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix Paun, Maria-Alexandra Paun, Vladimir-Alexandru Paun, Viorel-Puiu Gels Article A suite of four drug deliverance formulations grounded on 5-fluorouracil enclosed in a chitosan-founded intercellular substance was produced by 3,7-dimethyl-2,6-octadienal with in situ hydrogelation. The formulations have been examined from a morphological and structural point of view by Fourier transform infrared (FTIR) spectroscopy and microscopy with polarized light, respectively. The polarized optical microscopy (POM) pictures of the three representative formulations obtained were investigated by fractal analysis. The fractal dimension and lacunarity of each of them were thus calculated. In this paper, a novel theoretical method for mathematically describing medicament deliverance dynamics in the context of the polymeric medicament constitution limit has been advanced. Assuming that the polymeric drug motion unfolds only on the so-called non-differentiable curves (considered mathematically multifractal curves), it looks like in a one-dimensional hydrodynamic movement within a multifractal formalism, the drug-release physics models are provided by isochronous kinetics, but at a scale of resolution necessarily non-differentiable. MDPI 2022-10-16 /pmc/articles/PMC9602036/ /pubmed/36286162 http://dx.doi.org/10.3390/gels8100661 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Paun, Maria-Alexandra Paun, Vladimir-Alexandru Paun, Viorel-Puiu A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix |
title | A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix |
title_full | A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix |
title_fullStr | A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix |
title_full_unstemmed | A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix |
title_short | A Multifractal Vision of 5-Fluorouracil Release from Chitosan-Based Matrix |
title_sort | multifractal vision of 5-fluorouracil release from chitosan-based matrix |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602036/ https://www.ncbi.nlm.nih.gov/pubmed/36286162 http://dx.doi.org/10.3390/gels8100661 |
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