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Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women

Metabolic syndrome (MetSyn) is a precursor for several cardiometabolic diseases. The prevalence of MetSyn is higher in postmenopausal women compared to premenopausal women. The role of vitamin D in postmenopausal women is not clearly understood. Hypovitaminosis D is more prevalent in postmenopausal...

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Detalles Bibliográficos
Autores principales: Abuhijleh, Haya, Alkhatib, Dana, Ganji, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602081/
https://www.ncbi.nlm.nih.gov/pubmed/36292473
http://dx.doi.org/10.3390/healthcare10102026
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author Abuhijleh, Haya
Alkhatib, Dana
Ganji, Vijay
author_facet Abuhijleh, Haya
Alkhatib, Dana
Ganji, Vijay
author_sort Abuhijleh, Haya
collection PubMed
description Metabolic syndrome (MetSyn) is a precursor for several cardiometabolic diseases. The prevalence of MetSyn is higher in postmenopausal women compared to premenopausal women. The role of vitamin D in postmenopausal women is not clearly understood. Hypovitaminosis D is more prevalent in postmenopausal women compared to premenopausal women. For this review, Pubmed, Cochrane, SCOPUS, Embase, and Google Scholar databases were searched up to August 2022. Findings from one randomized controlled trial (RCT) and ten cross-sectional studies were included in this review. Several cross-sectional studies (8 out of 10 reviewed) unequivocally demonstrated an inverse association between serum 25-hydroxyvitamin D concentrations and MetSyn. However, RCTs are severely lacking in the effect of vitamin D intake on the biomarkers of MetSyn and the prevalence of MetSyn. Therefore, caution should be used in recommending mega doses of vitamin D supplements for postmenopausal women because of the potential adverse effects associated with this vitamer.
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spelling pubmed-96020812022-10-27 Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women Abuhijleh, Haya Alkhatib, Dana Ganji, Vijay Healthcare (Basel) Review Metabolic syndrome (MetSyn) is a precursor for several cardiometabolic diseases. The prevalence of MetSyn is higher in postmenopausal women compared to premenopausal women. The role of vitamin D in postmenopausal women is not clearly understood. Hypovitaminosis D is more prevalent in postmenopausal women compared to premenopausal women. For this review, Pubmed, Cochrane, SCOPUS, Embase, and Google Scholar databases were searched up to August 2022. Findings from one randomized controlled trial (RCT) and ten cross-sectional studies were included in this review. Several cross-sectional studies (8 out of 10 reviewed) unequivocally demonstrated an inverse association between serum 25-hydroxyvitamin D concentrations and MetSyn. However, RCTs are severely lacking in the effect of vitamin D intake on the biomarkers of MetSyn and the prevalence of MetSyn. Therefore, caution should be used in recommending mega doses of vitamin D supplements for postmenopausal women because of the potential adverse effects associated with this vitamer. MDPI 2022-10-14 /pmc/articles/PMC9602081/ /pubmed/36292473 http://dx.doi.org/10.3390/healthcare10102026 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abuhijleh, Haya
Alkhatib, Dana
Ganji, Vijay
Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women
title Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women
title_full Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women
title_fullStr Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women
title_full_unstemmed Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women
title_short Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women
title_sort hypovitaminosis d and metabolic syndrome in postmenopausal women
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602081/
https://www.ncbi.nlm.nih.gov/pubmed/36292473
http://dx.doi.org/10.3390/healthcare10102026
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