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Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature

BACKGROUND: Vitamin K(1 )(phytomenadione) is a fat-soluble naturally occurring vitamin that is widely used to treat certain coagulation disorders. Adverse cutaneous reactions to vitamin K(1 )can occur; however, owing to its low incidence and considerable variability in presentation and morphology, i...

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Autores principales: Zhang, Miao, Chen, Jia, Wang, Chun-Xiao, Lin, Nai-Xuan, Li, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602232/
https://www.ncbi.nlm.nih.gov/pubmed/36312487
http://dx.doi.org/10.12998/wjcc.v10.i29.10742
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author Zhang, Miao
Chen, Jia
Wang, Chun-Xiao
Lin, Nai-Xuan
Li, Xin
author_facet Zhang, Miao
Chen, Jia
Wang, Chun-Xiao
Lin, Nai-Xuan
Li, Xin
author_sort Zhang, Miao
collection PubMed
description BACKGROUND: Vitamin K(1 )(phytomenadione) is a fat-soluble naturally occurring vitamin that is widely used to treat certain coagulation disorders. Adverse cutaneous reactions to vitamin K(1 )can occur; however, owing to its low incidence and considerable variability in presentation and morphology, its diagnosis can be easily overlooked. Managing these reactions may be challenging for patients and clinicians. Therefore, reviewing the adverse cutaneous reactions to vitamin K(1 )is important. CASE SUMMARY: Here we report the case of a 50-year-old woman with no pre-existing hepatic disease who developed a cutaneous allergic reaction to subcutaneous vitamin K(1 )that presented as localized eczematous plaques at the vitamin K(1 )injection site. The eruption developed within 5 d of the injection and persisted for 32 mo despite treatment with topical and intralesional steroids. Eczema was diagnosed based on the results of the pathological examination, immunohistochemical staining, and a skin biopsy. The patient was advised to take herbal medicines orally twice daily. After treatment and follow-up, the patient’s eczematous urticarial plaques improved and her condition stabilized. CONCLUSION: Here we present the first case of a cutaneous allergic reaction to subcutaneous vitamin K(1 )that was successfully treated with Chinese medicine.
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spelling pubmed-96022322022-10-27 Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature Zhang, Miao Chen, Jia Wang, Chun-Xiao Lin, Nai-Xuan Li, Xin World J Clin Cases Case Report BACKGROUND: Vitamin K(1 )(phytomenadione) is a fat-soluble naturally occurring vitamin that is widely used to treat certain coagulation disorders. Adverse cutaneous reactions to vitamin K(1 )can occur; however, owing to its low incidence and considerable variability in presentation and morphology, its diagnosis can be easily overlooked. Managing these reactions may be challenging for patients and clinicians. Therefore, reviewing the adverse cutaneous reactions to vitamin K(1 )is important. CASE SUMMARY: Here we report the case of a 50-year-old woman with no pre-existing hepatic disease who developed a cutaneous allergic reaction to subcutaneous vitamin K(1 )that presented as localized eczematous plaques at the vitamin K(1 )injection site. The eruption developed within 5 d of the injection and persisted for 32 mo despite treatment with topical and intralesional steroids. Eczema was diagnosed based on the results of the pathological examination, immunohistochemical staining, and a skin biopsy. The patient was advised to take herbal medicines orally twice daily. After treatment and follow-up, the patient’s eczematous urticarial plaques improved and her condition stabilized. CONCLUSION: Here we present the first case of a cutaneous allergic reaction to subcutaneous vitamin K(1 )that was successfully treated with Chinese medicine. Baishideng Publishing Group Inc 2022-10-16 2022-10-16 /pmc/articles/PMC9602232/ /pubmed/36312487 http://dx.doi.org/10.12998/wjcc.v10.i29.10742 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Report
Zhang, Miao
Chen, Jia
Wang, Chun-Xiao
Lin, Nai-Xuan
Li, Xin
Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature
title Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature
title_full Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature
title_fullStr Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature
title_full_unstemmed Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature
title_short Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature
title_sort cutaneous allergic reaction to subcutaneous vitamin k(1): a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602232/
https://www.ncbi.nlm.nih.gov/pubmed/36312487
http://dx.doi.org/10.12998/wjcc.v10.i29.10742
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