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Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature
BACKGROUND: Vitamin K(1 )(phytomenadione) is a fat-soluble naturally occurring vitamin that is widely used to treat certain coagulation disorders. Adverse cutaneous reactions to vitamin K(1 )can occur; however, owing to its low incidence and considerable variability in presentation and morphology, i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602232/ https://www.ncbi.nlm.nih.gov/pubmed/36312487 http://dx.doi.org/10.12998/wjcc.v10.i29.10742 |
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author | Zhang, Miao Chen, Jia Wang, Chun-Xiao Lin, Nai-Xuan Li, Xin |
author_facet | Zhang, Miao Chen, Jia Wang, Chun-Xiao Lin, Nai-Xuan Li, Xin |
author_sort | Zhang, Miao |
collection | PubMed |
description | BACKGROUND: Vitamin K(1 )(phytomenadione) is a fat-soluble naturally occurring vitamin that is widely used to treat certain coagulation disorders. Adverse cutaneous reactions to vitamin K(1 )can occur; however, owing to its low incidence and considerable variability in presentation and morphology, its diagnosis can be easily overlooked. Managing these reactions may be challenging for patients and clinicians. Therefore, reviewing the adverse cutaneous reactions to vitamin K(1 )is important. CASE SUMMARY: Here we report the case of a 50-year-old woman with no pre-existing hepatic disease who developed a cutaneous allergic reaction to subcutaneous vitamin K(1 )that presented as localized eczematous plaques at the vitamin K(1 )injection site. The eruption developed within 5 d of the injection and persisted for 32 mo despite treatment with topical and intralesional steroids. Eczema was diagnosed based on the results of the pathological examination, immunohistochemical staining, and a skin biopsy. The patient was advised to take herbal medicines orally twice daily. After treatment and follow-up, the patient’s eczematous urticarial plaques improved and her condition stabilized. CONCLUSION: Here we present the first case of a cutaneous allergic reaction to subcutaneous vitamin K(1 )that was successfully treated with Chinese medicine. |
format | Online Article Text |
id | pubmed-9602232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-96022322022-10-27 Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature Zhang, Miao Chen, Jia Wang, Chun-Xiao Lin, Nai-Xuan Li, Xin World J Clin Cases Case Report BACKGROUND: Vitamin K(1 )(phytomenadione) is a fat-soluble naturally occurring vitamin that is widely used to treat certain coagulation disorders. Adverse cutaneous reactions to vitamin K(1 )can occur; however, owing to its low incidence and considerable variability in presentation and morphology, its diagnosis can be easily overlooked. Managing these reactions may be challenging for patients and clinicians. Therefore, reviewing the adverse cutaneous reactions to vitamin K(1 )is important. CASE SUMMARY: Here we report the case of a 50-year-old woman with no pre-existing hepatic disease who developed a cutaneous allergic reaction to subcutaneous vitamin K(1 )that presented as localized eczematous plaques at the vitamin K(1 )injection site. The eruption developed within 5 d of the injection and persisted for 32 mo despite treatment with topical and intralesional steroids. Eczema was diagnosed based on the results of the pathological examination, immunohistochemical staining, and a skin biopsy. The patient was advised to take herbal medicines orally twice daily. After treatment and follow-up, the patient’s eczematous urticarial plaques improved and her condition stabilized. CONCLUSION: Here we present the first case of a cutaneous allergic reaction to subcutaneous vitamin K(1 )that was successfully treated with Chinese medicine. Baishideng Publishing Group Inc 2022-10-16 2022-10-16 /pmc/articles/PMC9602232/ /pubmed/36312487 http://dx.doi.org/10.12998/wjcc.v10.i29.10742 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Case Report Zhang, Miao Chen, Jia Wang, Chun-Xiao Lin, Nai-Xuan Li, Xin Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature |
title | Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature |
title_full | Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature |
title_fullStr | Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature |
title_full_unstemmed | Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature |
title_short | Cutaneous allergic reaction to subcutaneous vitamin K(1): A case report and review of literature |
title_sort | cutaneous allergic reaction to subcutaneous vitamin k(1): a case report and review of literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602232/ https://www.ncbi.nlm.nih.gov/pubmed/36312487 http://dx.doi.org/10.12998/wjcc.v10.i29.10742 |
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