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Noise in a Metabolic Pathway Leads to Persister Formation in Mycobacterium tuberculosis
Tuberculosis is difficult to treat due to dormant cells formed in response to immune stress and stochastically formed persisters, both of which are tolerant of antibiotics. Bactericidal antibiotics kill by corrupting their energy-dependent targets. We reasoned that stochastic variation, or noise, in...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Microbiology
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602276/ https://www.ncbi.nlm.nih.gov/pubmed/36194154 http://dx.doi.org/10.1128/spectrum.02948-22 |