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New Genetic Biomarkers of the Overlap Syndrome Tension-Type Headache and Arterial Hypertension

Background: Nitric oxide (NO) is an important autocrine and paracrine signaling molecule that plays a crucial role in cardiovascular physiology and pathology regulation. NO is an important molecule involved in regulation of cerebral and extra cerebral cranial blood flow and arterial diameters. Reduc...

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Autores principales: Alyabyeva, Polina V., Chastina, Olga V., Petrova, Marina M., Lareva, Natalia V., Garganeeva, Natalia P., Chumakova, Galina A., Cherniaeva, Marina S., Shnayder, Natalia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602376/
https://www.ncbi.nlm.nih.gov/pubmed/36292708
http://dx.doi.org/10.3390/genes13101823
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author Alyabyeva, Polina V.
Chastina, Olga V.
Petrova, Marina M.
Lareva, Natalia V.
Garganeeva, Natalia P.
Chumakova, Galina A.
Cherniaeva, Marina S.
Shnayder, Natalia A.
author_facet Alyabyeva, Polina V.
Chastina, Olga V.
Petrova, Marina M.
Lareva, Natalia V.
Garganeeva, Natalia P.
Chumakova, Galina A.
Cherniaeva, Marina S.
Shnayder, Natalia A.
author_sort Alyabyeva, Polina V.
collection PubMed
description Background: Nitric oxide (NO) is an important autocrine and paracrine signaling molecule that plays a crucial role in cardiovascular physiology and pathology regulation. NO is an important molecule involved in regulation of cerebral and extra cerebral cranial blood flow and arterial diameters. Reduced bioavailability of NO in the endothelium is an important precursor for impaired vasodilation and arterial hypertension (AH). Furthermore, NO is involved in nociceptive processing. A NO-induced biphasic response with immediate and a delayed headache is typical for chronic tension-type headaches (TTH) in humans. The aim was to study the association of allelic variants and genotypes of the single nucleotide variant (SNV) rs3782218 of the NOS1 gene with the TTH and AH overlap syndrome development in middle age adults. Materials and Methods: We observed 91 Caucasian participants who resided in Krasnoyarsk city: group 1 (TTH and AH overlap syndrome)—30 patients; group 2 (AH without headache)—30 patients; group 3 (control)—31 healthy volunteers. The diagnosis of AH was based on criteria of the European Society of Cardiology and the European Society of Hypertension (2018) и criteria of the Russian Society of Cardiology (2020). Diagnosis of TTH was based on criteria of the International Classification of Headache Disorders (2018). Real-time polymerase chain reaction was used for the determination of allelic variants and genotypes of the SNV rs3782218 of the NOS1 gene in all groups of participants. Results: The frequency of the minor allele T of rs3782218 was statistically significantly higher by 16.7 times in group 1 (TTH and AH) compared to group 3 (control): 26.7% versus 1.6%, respectively (p-value = 0.000065) and 3.2 times higher in group 1 (TTH and AH) compared to group 2 (AH without headache): 26.7% versus 8.3%, respectively (p-value = 0.008). The frequency of the heterozygous (CT) genotype was statistically significantly higher in group 1 (TTH and AH) compared to group 3 (control): 40.0% versus 3.2% (p-value = 0.000454) and in group 1 (TTH and AH) compared to group 2 (AH without headache): 40.0% versus 16.7% (p-value = 0.045). The minor allele T was statistically significantly associated with a high risk of developing the TTH and AH overlap syndrome compared with the controls (odds ratio (OR) = 22.2 (95% confidential interval (CI): 2.8–173.5)) and compared with AH without headache (OR = 4.0 (95% CI: 1.4–11.8)). Although the frequency of the minor allele T was 5.2 times higher in group 2 (AH without headache) compared with group 3 (control), there were not statistically significantly differences (p-value = 0.086). Conclusion: Thus, the minor allele T of rs3782218 of the NOS1 gene is an important genetic biomarker for a high risk of developing the TTH and AH overlap syndrome in hypertensive patients.
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spelling pubmed-96023762022-10-27 New Genetic Biomarkers of the Overlap Syndrome Tension-Type Headache and Arterial Hypertension Alyabyeva, Polina V. Chastina, Olga V. Petrova, Marina M. Lareva, Natalia V. Garganeeva, Natalia P. Chumakova, Galina A. Cherniaeva, Marina S. Shnayder, Natalia A. Genes (Basel) Article Background: Nitric oxide (NO) is an important autocrine and paracrine signaling molecule that plays a crucial role in cardiovascular physiology and pathology regulation. NO is an important molecule involved in regulation of cerebral and extra cerebral cranial blood flow and arterial diameters. Reduced bioavailability of NO in the endothelium is an important precursor for impaired vasodilation and arterial hypertension (AH). Furthermore, NO is involved in nociceptive processing. A NO-induced biphasic response with immediate and a delayed headache is typical for chronic tension-type headaches (TTH) in humans. The aim was to study the association of allelic variants and genotypes of the single nucleotide variant (SNV) rs3782218 of the NOS1 gene with the TTH and AH overlap syndrome development in middle age adults. Materials and Methods: We observed 91 Caucasian participants who resided in Krasnoyarsk city: group 1 (TTH and AH overlap syndrome)—30 patients; group 2 (AH without headache)—30 patients; group 3 (control)—31 healthy volunteers. The diagnosis of AH was based on criteria of the European Society of Cardiology and the European Society of Hypertension (2018) и criteria of the Russian Society of Cardiology (2020). Diagnosis of TTH was based on criteria of the International Classification of Headache Disorders (2018). Real-time polymerase chain reaction was used for the determination of allelic variants and genotypes of the SNV rs3782218 of the NOS1 gene in all groups of participants. Results: The frequency of the minor allele T of rs3782218 was statistically significantly higher by 16.7 times in group 1 (TTH and AH) compared to group 3 (control): 26.7% versus 1.6%, respectively (p-value = 0.000065) and 3.2 times higher in group 1 (TTH and AH) compared to group 2 (AH without headache): 26.7% versus 8.3%, respectively (p-value = 0.008). The frequency of the heterozygous (CT) genotype was statistically significantly higher in group 1 (TTH and AH) compared to group 3 (control): 40.0% versus 3.2% (p-value = 0.000454) and in group 1 (TTH and AH) compared to group 2 (AH without headache): 40.0% versus 16.7% (p-value = 0.045). The minor allele T was statistically significantly associated with a high risk of developing the TTH and AH overlap syndrome compared with the controls (odds ratio (OR) = 22.2 (95% confidential interval (CI): 2.8–173.5)) and compared with AH without headache (OR = 4.0 (95% CI: 1.4–11.8)). Although the frequency of the minor allele T was 5.2 times higher in group 2 (AH without headache) compared with group 3 (control), there were not statistically significantly differences (p-value = 0.086). Conclusion: Thus, the minor allele T of rs3782218 of the NOS1 gene is an important genetic biomarker for a high risk of developing the TTH and AH overlap syndrome in hypertensive patients. MDPI 2022-10-09 /pmc/articles/PMC9602376/ /pubmed/36292708 http://dx.doi.org/10.3390/genes13101823 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alyabyeva, Polina V.
Chastina, Olga V.
Petrova, Marina M.
Lareva, Natalia V.
Garganeeva, Natalia P.
Chumakova, Galina A.
Cherniaeva, Marina S.
Shnayder, Natalia A.
New Genetic Biomarkers of the Overlap Syndrome Tension-Type Headache and Arterial Hypertension
title New Genetic Biomarkers of the Overlap Syndrome Tension-Type Headache and Arterial Hypertension
title_full New Genetic Biomarkers of the Overlap Syndrome Tension-Type Headache and Arterial Hypertension
title_fullStr New Genetic Biomarkers of the Overlap Syndrome Tension-Type Headache and Arterial Hypertension
title_full_unstemmed New Genetic Biomarkers of the Overlap Syndrome Tension-Type Headache and Arterial Hypertension
title_short New Genetic Biomarkers of the Overlap Syndrome Tension-Type Headache and Arterial Hypertension
title_sort new genetic biomarkers of the overlap syndrome tension-type headache and arterial hypertension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602376/
https://www.ncbi.nlm.nih.gov/pubmed/36292708
http://dx.doi.org/10.3390/genes13101823
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