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Correlation between Lindane Use and the Incidence of Thyroid Cancer in the United States: An Ecological Study

The increasing rate of thyroid cancer may be attributable to endocrine disruptive chemicals. Lindane is a persistent organochlorine pesticide with endocrine disruptive properties that has been classified as carcinogenic to humans. The aim of this ecological study was to evaluate potential correlatio...

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Autores principales: Alsen, Mathilda, Vasan, Vikram, Genden, Eric M., Sinclair, Catherine, van Gerwen, Maaike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602460/
https://www.ncbi.nlm.nih.gov/pubmed/36293736
http://dx.doi.org/10.3390/ijerph192013158
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author Alsen, Mathilda
Vasan, Vikram
Genden, Eric M.
Sinclair, Catherine
van Gerwen, Maaike
author_facet Alsen, Mathilda
Vasan, Vikram
Genden, Eric M.
Sinclair, Catherine
van Gerwen, Maaike
author_sort Alsen, Mathilda
collection PubMed
description The increasing rate of thyroid cancer may be attributable to endocrine disruptive chemicals. Lindane is a persistent organochlorine pesticide with endocrine disruptive properties that has been classified as carcinogenic to humans. The aim of this ecological study was to evaluate potential correlation between lindane exposure and thyroid cancer incidence in the United States (US). Data on statewide age-adjusted thyroid cancer incidence rate (per 100,000 people) was obtained from the Centers for Disease Control and Prevention for all US states for 2019. Lindane use estimates per cropland (kg/acres cropland) were then overlaid on the map of age-adjusted thyroid cancer incidence rate using ArcGIS. The trend of lindane use in the US between 1992 and 2007 was calculated using the Mann Kendall correlation test. The correlation between statewide lindane use and age-adjusted thyroid cancer incidence rates was calculated using Spearman correlation. Lindane use in the US decreased significantly between 1992 and 2007 (T = −0.617; p < 0.001). There was no statistically significant correlation between lindane use in 1992 and thyroid cancer incidence rate for any of the years between 1999 and 2019. Our results suggest that restrictions clearly seem to be effective in reducing lindane use, however, more research is needed for individual pesticides and thyroid cancer.
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spelling pubmed-96024602022-10-27 Correlation between Lindane Use and the Incidence of Thyroid Cancer in the United States: An Ecological Study Alsen, Mathilda Vasan, Vikram Genden, Eric M. Sinclair, Catherine van Gerwen, Maaike Int J Environ Res Public Health Article The increasing rate of thyroid cancer may be attributable to endocrine disruptive chemicals. Lindane is a persistent organochlorine pesticide with endocrine disruptive properties that has been classified as carcinogenic to humans. The aim of this ecological study was to evaluate potential correlation between lindane exposure and thyroid cancer incidence in the United States (US). Data on statewide age-adjusted thyroid cancer incidence rate (per 100,000 people) was obtained from the Centers for Disease Control and Prevention for all US states for 2019. Lindane use estimates per cropland (kg/acres cropland) were then overlaid on the map of age-adjusted thyroid cancer incidence rate using ArcGIS. The trend of lindane use in the US between 1992 and 2007 was calculated using the Mann Kendall correlation test. The correlation between statewide lindane use and age-adjusted thyroid cancer incidence rates was calculated using Spearman correlation. Lindane use in the US decreased significantly between 1992 and 2007 (T = −0.617; p < 0.001). There was no statistically significant correlation between lindane use in 1992 and thyroid cancer incidence rate for any of the years between 1999 and 2019. Our results suggest that restrictions clearly seem to be effective in reducing lindane use, however, more research is needed for individual pesticides and thyroid cancer. MDPI 2022-10-13 /pmc/articles/PMC9602460/ /pubmed/36293736 http://dx.doi.org/10.3390/ijerph192013158 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alsen, Mathilda
Vasan, Vikram
Genden, Eric M.
Sinclair, Catherine
van Gerwen, Maaike
Correlation between Lindane Use and the Incidence of Thyroid Cancer in the United States: An Ecological Study
title Correlation between Lindane Use and the Incidence of Thyroid Cancer in the United States: An Ecological Study
title_full Correlation between Lindane Use and the Incidence of Thyroid Cancer in the United States: An Ecological Study
title_fullStr Correlation between Lindane Use and the Incidence of Thyroid Cancer in the United States: An Ecological Study
title_full_unstemmed Correlation between Lindane Use and the Incidence of Thyroid Cancer in the United States: An Ecological Study
title_short Correlation between Lindane Use and the Incidence of Thyroid Cancer in the United States: An Ecological Study
title_sort correlation between lindane use and the incidence of thyroid cancer in the united states: an ecological study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602460/
https://www.ncbi.nlm.nih.gov/pubmed/36293736
http://dx.doi.org/10.3390/ijerph192013158
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