Cargando…
Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients
We investigated whether a functional insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) influenced antipsychotic treatment. At baseline, and after 8 weeks of treatment with various antipsychotic medications, we assessed patients’ Positive and Negative Syndrome Scale (PANSS)...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602538/ https://www.ncbi.nlm.nih.gov/pubmed/36293037 http://dx.doi.org/10.3390/ijms232012180 |
_version_ | 1784817343280447488 |
---|---|
author | Nadalin, Sergej Dević Pavlić, Sanja Peitl, Vjekoslav Karlović, Dalibor Zatković, Lena Ristić, Smiljana Buretić-Tomljanović, Alena Jakovac, Hrvoje |
author_facet | Nadalin, Sergej Dević Pavlić, Sanja Peitl, Vjekoslav Karlović, Dalibor Zatković, Lena Ristić, Smiljana Buretić-Tomljanović, Alena Jakovac, Hrvoje |
author_sort | Nadalin, Sergej |
collection | PubMed |
description | We investigated whether a functional insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) influenced antipsychotic treatment. At baseline, and after 8 weeks of treatment with various antipsychotic medications, we assessed patients’ Positive and Negative Syndrome Scale (PANSS) scores, PANSS factors, and metabolic-syndrome-related parameters (fasting plasma lipid and glucose levels, and body mass index). A total of 186 antipsychotic-naïve first-episode psychosis patients or nonadherent chronic psychosis individuals (99 males and 87 females) were genotyped by polymerase chain reaction analysis. The ACE-I/D polymorphism was significantly associated with changes in PANSS psychopathology only (p < 0.05). Compared to ACE-II homozygous males, ACE-DD homozygous and ACE-ID heterozygous males manifested significantly greater decreases in PANSS positive score, PANSS excitement factor, and PANSS cognitive factor. ACE-DD homozygous females manifested higher decreases in PANSS depression factor compared to ACE-II homozygous and ACE-ID heterozygous females. The polymorphism’s effect size was estimated as moderate to strong, while its contribution to the PANSS psychopathology ranged from ~5.4 to 8.7%, with the lowest contribution observed for PANSS positive score changes and the highest for PANSS depressive factor changes. Our results indicate that ACE-I/D polymorphism had a statistically significant but weak gender-specific impact on psychopathology data, and showed no association between ACE-I/D polymorphism and metabolic-syndrome-related parameters. |
format | Online Article Text |
id | pubmed-9602538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96025382022-10-27 Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients Nadalin, Sergej Dević Pavlić, Sanja Peitl, Vjekoslav Karlović, Dalibor Zatković, Lena Ristić, Smiljana Buretić-Tomljanović, Alena Jakovac, Hrvoje Int J Mol Sci Article We investigated whether a functional insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) influenced antipsychotic treatment. At baseline, and after 8 weeks of treatment with various antipsychotic medications, we assessed patients’ Positive and Negative Syndrome Scale (PANSS) scores, PANSS factors, and metabolic-syndrome-related parameters (fasting plasma lipid and glucose levels, and body mass index). A total of 186 antipsychotic-naïve first-episode psychosis patients or nonadherent chronic psychosis individuals (99 males and 87 females) were genotyped by polymerase chain reaction analysis. The ACE-I/D polymorphism was significantly associated with changes in PANSS psychopathology only (p < 0.05). Compared to ACE-II homozygous males, ACE-DD homozygous and ACE-ID heterozygous males manifested significantly greater decreases in PANSS positive score, PANSS excitement factor, and PANSS cognitive factor. ACE-DD homozygous females manifested higher decreases in PANSS depression factor compared to ACE-II homozygous and ACE-ID heterozygous females. The polymorphism’s effect size was estimated as moderate to strong, while its contribution to the PANSS psychopathology ranged from ~5.4 to 8.7%, with the lowest contribution observed for PANSS positive score changes and the highest for PANSS depressive factor changes. Our results indicate that ACE-I/D polymorphism had a statistically significant but weak gender-specific impact on psychopathology data, and showed no association between ACE-I/D polymorphism and metabolic-syndrome-related parameters. MDPI 2022-10-12 /pmc/articles/PMC9602538/ /pubmed/36293037 http://dx.doi.org/10.3390/ijms232012180 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nadalin, Sergej Dević Pavlić, Sanja Peitl, Vjekoslav Karlović, Dalibor Zatković, Lena Ristić, Smiljana Buretić-Tomljanović, Alena Jakovac, Hrvoje Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients |
title | Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients |
title_full | Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients |
title_fullStr | Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients |
title_full_unstemmed | Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients |
title_short | Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients |
title_sort | association between insertion-deletion polymorphism of the angiotensin-converting enzyme gene and treatment response to antipsychotic medications: a study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602538/ https://www.ncbi.nlm.nih.gov/pubmed/36293037 http://dx.doi.org/10.3390/ijms232012180 |
work_keys_str_mv | AT nadalinsergej associationbetweeninsertiondeletionpolymorphismoftheangiotensinconvertingenzymegeneandtreatmentresponsetoantipsychoticmedicationsastudyofantipsychoticnaivefirstepisodepsychosispatientsandnonadherentchronicpsychosispatients AT devicpavlicsanja associationbetweeninsertiondeletionpolymorphismoftheangiotensinconvertingenzymegeneandtreatmentresponsetoantipsychoticmedicationsastudyofantipsychoticnaivefirstepisodepsychosispatientsandnonadherentchronicpsychosispatients AT peitlvjekoslav associationbetweeninsertiondeletionpolymorphismoftheangiotensinconvertingenzymegeneandtreatmentresponsetoantipsychoticmedicationsastudyofantipsychoticnaivefirstepisodepsychosispatientsandnonadherentchronicpsychosispatients AT karlovicdalibor associationbetweeninsertiondeletionpolymorphismoftheangiotensinconvertingenzymegeneandtreatmentresponsetoantipsychoticmedicationsastudyofantipsychoticnaivefirstepisodepsychosispatientsandnonadherentchronicpsychosispatients AT zatkoviclena associationbetweeninsertiondeletionpolymorphismoftheangiotensinconvertingenzymegeneandtreatmentresponsetoantipsychoticmedicationsastudyofantipsychoticnaivefirstepisodepsychosispatientsandnonadherentchronicpsychosispatients AT risticsmiljana associationbetweeninsertiondeletionpolymorphismoftheangiotensinconvertingenzymegeneandtreatmentresponsetoantipsychoticmedicationsastudyofantipsychoticnaivefirstepisodepsychosispatientsandnonadherentchronicpsychosispatients AT buretictomljanovicalena associationbetweeninsertiondeletionpolymorphismoftheangiotensinconvertingenzymegeneandtreatmentresponsetoantipsychoticmedicationsastudyofantipsychoticnaivefirstepisodepsychosispatientsandnonadherentchronicpsychosispatients AT jakovachrvoje associationbetweeninsertiondeletionpolymorphismoftheangiotensinconvertingenzymegeneandtreatmentresponsetoantipsychoticmedicationsastudyofantipsychoticnaivefirstepisodepsychosispatientsandnonadherentchronicpsychosispatients |