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Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer
Background: Anxiety and depression are common in patients with cancer. The aim of this study is to determine the prevalence of anxiety and depression symptoms in colorectal cancer (CRC) patients awaiting elective surgery and whether there is an association with their preoperative nutritional status...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602641/ https://www.ncbi.nlm.nih.gov/pubmed/36294130 http://dx.doi.org/10.3390/ijerph192013548 |
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author | Soria-Utrilla, Virginia Sánchez-Torralvo, Francisco José González-Poveda, Iván Mera-Velasco, Santiago Porras, Nuria Toval-Mata, José Antonio García-Olivares, María Ruiz-López, Manuel Gonzalo-Marín, Montserrat Carrasco-Campos, Joaquín Tapia, María José Santoyo-Santoyo, Julio Olveira, Gabriel |
author_facet | Soria-Utrilla, Virginia Sánchez-Torralvo, Francisco José González-Poveda, Iván Mera-Velasco, Santiago Porras, Nuria Toval-Mata, José Antonio García-Olivares, María Ruiz-López, Manuel Gonzalo-Marín, Montserrat Carrasco-Campos, Joaquín Tapia, María José Santoyo-Santoyo, Julio Olveira, Gabriel |
author_sort | Soria-Utrilla, Virginia |
collection | PubMed |
description | Background: Anxiety and depression are common in patients with cancer. The aim of this study is to determine the prevalence of anxiety and depression symptoms in colorectal cancer (CRC) patients awaiting elective surgery and whether there is an association with their preoperative nutritional status and postoperative mortality. Methods: A prospective study was conducted on 215 patients with CRC proposed for surgery. Data about nutritional status were collected using the Global Leadership Initiative on Malnutrition (GLIM) criteria, while anxiety and depression symptoms data were collected using Hospital Anxiety and Depression Scale (HADS). Results: HADS detected possible anxiety in 41.9% of patients, probable anxiety in 25.6%, possible depression in 21.9%, and probable depression in 7.9%. GLIM criteria found 116 (53.9%) patients with malnutrition. The HADS score for depression subscale was significantly higher in malnourished patients than in well-nourished (5.61 ± 3.65 vs. 3.95 ± 2.68; p = 0.001). After controlling for potential confounders, malnourished patients were 10.19 times more likely to present probable depression (95% CI 1.13–92.24; p = 0.039). Mortality was 1.9%, 4,2%, and 5.6% during admission and after 6 and 12 months, respectively. Compared to patients without depressive symptomatology, in patients with probable depression, mortality risk was 14.67 times greater (95% CI 1.54–140.21; p = 0.02) during admission and 6.62 times greater (95% CI 1.34–32.61; p = 0.02) after 6 months. Conclusions: The presence of anxiety and depression symptoms in CRC patients awaiting elective surgery is high. There is an association between depression symptoms, preoperative nutritional status, and postoperative mortality. |
format | Online Article Text |
id | pubmed-9602641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96026412022-10-27 Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer Soria-Utrilla, Virginia Sánchez-Torralvo, Francisco José González-Poveda, Iván Mera-Velasco, Santiago Porras, Nuria Toval-Mata, José Antonio García-Olivares, María Ruiz-López, Manuel Gonzalo-Marín, Montserrat Carrasco-Campos, Joaquín Tapia, María José Santoyo-Santoyo, Julio Olveira, Gabriel Int J Environ Res Public Health Article Background: Anxiety and depression are common in patients with cancer. The aim of this study is to determine the prevalence of anxiety and depression symptoms in colorectal cancer (CRC) patients awaiting elective surgery and whether there is an association with their preoperative nutritional status and postoperative mortality. Methods: A prospective study was conducted on 215 patients with CRC proposed for surgery. Data about nutritional status were collected using the Global Leadership Initiative on Malnutrition (GLIM) criteria, while anxiety and depression symptoms data were collected using Hospital Anxiety and Depression Scale (HADS). Results: HADS detected possible anxiety in 41.9% of patients, probable anxiety in 25.6%, possible depression in 21.9%, and probable depression in 7.9%. GLIM criteria found 116 (53.9%) patients with malnutrition. The HADS score for depression subscale was significantly higher in malnourished patients than in well-nourished (5.61 ± 3.65 vs. 3.95 ± 2.68; p = 0.001). After controlling for potential confounders, malnourished patients were 10.19 times more likely to present probable depression (95% CI 1.13–92.24; p = 0.039). Mortality was 1.9%, 4,2%, and 5.6% during admission and after 6 and 12 months, respectively. Compared to patients without depressive symptomatology, in patients with probable depression, mortality risk was 14.67 times greater (95% CI 1.54–140.21; p = 0.02) during admission and 6.62 times greater (95% CI 1.34–32.61; p = 0.02) after 6 months. Conclusions: The presence of anxiety and depression symptoms in CRC patients awaiting elective surgery is high. There is an association between depression symptoms, preoperative nutritional status, and postoperative mortality. MDPI 2022-10-19 /pmc/articles/PMC9602641/ /pubmed/36294130 http://dx.doi.org/10.3390/ijerph192013548 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Soria-Utrilla, Virginia Sánchez-Torralvo, Francisco José González-Poveda, Iván Mera-Velasco, Santiago Porras, Nuria Toval-Mata, José Antonio García-Olivares, María Ruiz-López, Manuel Gonzalo-Marín, Montserrat Carrasco-Campos, Joaquín Tapia, María José Santoyo-Santoyo, Julio Olveira, Gabriel Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer |
title | Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer |
title_full | Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer |
title_fullStr | Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer |
title_full_unstemmed | Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer |
title_short | Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer |
title_sort | prevalence of anxiety and depression symptoms and their relationship with nutritional status and mortality in patients with colorectal cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602641/ https://www.ncbi.nlm.nih.gov/pubmed/36294130 http://dx.doi.org/10.3390/ijerph192013548 |
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