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Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer

Background: Anxiety and depression are common in patients with cancer. The aim of this study is to determine the prevalence of anxiety and depression symptoms in colorectal cancer (CRC) patients awaiting elective surgery and whether there is an association with their preoperative nutritional status...

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Autores principales: Soria-Utrilla, Virginia, Sánchez-Torralvo, Francisco José, González-Poveda, Iván, Mera-Velasco, Santiago, Porras, Nuria, Toval-Mata, José Antonio, García-Olivares, María, Ruiz-López, Manuel, Gonzalo-Marín, Montserrat, Carrasco-Campos, Joaquín, Tapia, María José, Santoyo-Santoyo, Julio, Olveira, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602641/
https://www.ncbi.nlm.nih.gov/pubmed/36294130
http://dx.doi.org/10.3390/ijerph192013548
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author Soria-Utrilla, Virginia
Sánchez-Torralvo, Francisco José
González-Poveda, Iván
Mera-Velasco, Santiago
Porras, Nuria
Toval-Mata, José Antonio
García-Olivares, María
Ruiz-López, Manuel
Gonzalo-Marín, Montserrat
Carrasco-Campos, Joaquín
Tapia, María José
Santoyo-Santoyo, Julio
Olveira, Gabriel
author_facet Soria-Utrilla, Virginia
Sánchez-Torralvo, Francisco José
González-Poveda, Iván
Mera-Velasco, Santiago
Porras, Nuria
Toval-Mata, José Antonio
García-Olivares, María
Ruiz-López, Manuel
Gonzalo-Marín, Montserrat
Carrasco-Campos, Joaquín
Tapia, María José
Santoyo-Santoyo, Julio
Olveira, Gabriel
author_sort Soria-Utrilla, Virginia
collection PubMed
description Background: Anxiety and depression are common in patients with cancer. The aim of this study is to determine the prevalence of anxiety and depression symptoms in colorectal cancer (CRC) patients awaiting elective surgery and whether there is an association with their preoperative nutritional status and postoperative mortality. Methods: A prospective study was conducted on 215 patients with CRC proposed for surgery. Data about nutritional status were collected using the Global Leadership Initiative on Malnutrition (GLIM) criteria, while anxiety and depression symptoms data were collected using Hospital Anxiety and Depression Scale (HADS). Results: HADS detected possible anxiety in 41.9% of patients, probable anxiety in 25.6%, possible depression in 21.9%, and probable depression in 7.9%. GLIM criteria found 116 (53.9%) patients with malnutrition. The HADS score for depression subscale was significantly higher in malnourished patients than in well-nourished (5.61 ± 3.65 vs. 3.95 ± 2.68; p = 0.001). After controlling for potential confounders, malnourished patients were 10.19 times more likely to present probable depression (95% CI 1.13–92.24; p = 0.039). Mortality was 1.9%, 4,2%, and 5.6% during admission and after 6 and 12 months, respectively. Compared to patients without depressive symptomatology, in patients with probable depression, mortality risk was 14.67 times greater (95% CI 1.54–140.21; p = 0.02) during admission and 6.62 times greater (95% CI 1.34–32.61; p = 0.02) after 6 months. Conclusions: The presence of anxiety and depression symptoms in CRC patients awaiting elective surgery is high. There is an association between depression symptoms, preoperative nutritional status, and postoperative mortality.
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spelling pubmed-96026412022-10-27 Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer Soria-Utrilla, Virginia Sánchez-Torralvo, Francisco José González-Poveda, Iván Mera-Velasco, Santiago Porras, Nuria Toval-Mata, José Antonio García-Olivares, María Ruiz-López, Manuel Gonzalo-Marín, Montserrat Carrasco-Campos, Joaquín Tapia, María José Santoyo-Santoyo, Julio Olveira, Gabriel Int J Environ Res Public Health Article Background: Anxiety and depression are common in patients with cancer. The aim of this study is to determine the prevalence of anxiety and depression symptoms in colorectal cancer (CRC) patients awaiting elective surgery and whether there is an association with their preoperative nutritional status and postoperative mortality. Methods: A prospective study was conducted on 215 patients with CRC proposed for surgery. Data about nutritional status were collected using the Global Leadership Initiative on Malnutrition (GLIM) criteria, while anxiety and depression symptoms data were collected using Hospital Anxiety and Depression Scale (HADS). Results: HADS detected possible anxiety in 41.9% of patients, probable anxiety in 25.6%, possible depression in 21.9%, and probable depression in 7.9%. GLIM criteria found 116 (53.9%) patients with malnutrition. The HADS score for depression subscale was significantly higher in malnourished patients than in well-nourished (5.61 ± 3.65 vs. 3.95 ± 2.68; p = 0.001). After controlling for potential confounders, malnourished patients were 10.19 times more likely to present probable depression (95% CI 1.13–92.24; p = 0.039). Mortality was 1.9%, 4,2%, and 5.6% during admission and after 6 and 12 months, respectively. Compared to patients without depressive symptomatology, in patients with probable depression, mortality risk was 14.67 times greater (95% CI 1.54–140.21; p = 0.02) during admission and 6.62 times greater (95% CI 1.34–32.61; p = 0.02) after 6 months. Conclusions: The presence of anxiety and depression symptoms in CRC patients awaiting elective surgery is high. There is an association between depression symptoms, preoperative nutritional status, and postoperative mortality. MDPI 2022-10-19 /pmc/articles/PMC9602641/ /pubmed/36294130 http://dx.doi.org/10.3390/ijerph192013548 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Soria-Utrilla, Virginia
Sánchez-Torralvo, Francisco José
González-Poveda, Iván
Mera-Velasco, Santiago
Porras, Nuria
Toval-Mata, José Antonio
García-Olivares, María
Ruiz-López, Manuel
Gonzalo-Marín, Montserrat
Carrasco-Campos, Joaquín
Tapia, María José
Santoyo-Santoyo, Julio
Olveira, Gabriel
Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer
title Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer
title_full Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer
title_fullStr Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer
title_full_unstemmed Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer
title_short Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer
title_sort prevalence of anxiety and depression symptoms and their relationship with nutritional status and mortality in patients with colorectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602641/
https://www.ncbi.nlm.nih.gov/pubmed/36294130
http://dx.doi.org/10.3390/ijerph192013548
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