Preclinical evaluation of the epithelial sodium channel inhibitor AZD5634 and implications on human translation

Airway dehydration causes mucus stasis and bacterial overgrowth in cystic fibrosis (CF), resulting in recurrent respiratory infections and exacerbations. Strategies to rehydrate airway mucus including inhibition of the epithelial sodium channel (ENaC) have the potential to improve mucosal defense by...

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Detalles Bibliográficos
Autores principales: Åstrand, Annika, Libby, Emily Falk, Shei, Ren-Jay, Lever, Jacelyn E. Peabody, Kaza, Niroop, Adewale, Adegboyega Timothy, Boitet, Evan, Edwards, Lloyd, Hemmerling, Martin, Root, James, Lindberg, Botilda, Wingren, Cecilia, Malmgren, Anna, Sabater, Juan, Rowe, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602792/
https://www.ncbi.nlm.nih.gov/pubmed/36098422
http://dx.doi.org/10.1152/ajplung.00454.2021

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