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Meta-Analysis Reveals Challenges and Gaps for Genome-to-Phenome Research Underpinning Plant Drought Response

Severe drought conditions and extreme weather events are increasing worldwide with climate change, threatening the persistence of native plant communities and ecosystems. Many studies have investigated the genomic basis of plant responses to drought. However, the extent of this research throughout t...

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Autores principales: Melton, Anthony E., Galla, Stephanie J., Dumaguit, Carlos Dave C., Wojahn, John M. A., Novak, Stephen, Serpe, Marcelo, Martinez, Peggy, Buerki, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602940/
https://www.ncbi.nlm.nih.gov/pubmed/36293161
http://dx.doi.org/10.3390/ijms232012297
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author Melton, Anthony E.
Galla, Stephanie J.
Dumaguit, Carlos Dave C.
Wojahn, John M. A.
Novak, Stephen
Serpe, Marcelo
Martinez, Peggy
Buerki, Sven
author_facet Melton, Anthony E.
Galla, Stephanie J.
Dumaguit, Carlos Dave C.
Wojahn, John M. A.
Novak, Stephen
Serpe, Marcelo
Martinez, Peggy
Buerki, Sven
author_sort Melton, Anthony E.
collection PubMed
description Severe drought conditions and extreme weather events are increasing worldwide with climate change, threatening the persistence of native plant communities and ecosystems. Many studies have investigated the genomic basis of plant responses to drought. However, the extent of this research throughout the plant kingdom is unclear, particularly among species critical for the sustainability of natural ecosystems. This study aimed to broaden our understanding of genome-to-phenome (G2P) connections in drought-stressed plants and identify focal taxa for future research. Bioinformatics pipelines were developed to mine and link information from databases and abstracts from 7730 publications. This approach identified 1634 genes involved in drought responses among 497 plant taxa. Most (83.30%) of these species have been classified for human use, and most G2P interactions have been described within model organisms or crop species. Our analysis identifies several gaps in G2P research literature and database connectivity, with 21% of abstracts being linked to gene and taxonomy data in NCBI. Abstract text mining was more successful at identifying potential G2P pathways, with 34% of abstracts containing gene, taxa, and phenotype information. Expanding G2P studies to include non-model plants, especially those that are adapted to drought stress, will help advance our understanding of drought responsive G2P pathways.
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spelling pubmed-96029402022-10-27 Meta-Analysis Reveals Challenges and Gaps for Genome-to-Phenome Research Underpinning Plant Drought Response Melton, Anthony E. Galla, Stephanie J. Dumaguit, Carlos Dave C. Wojahn, John M. A. Novak, Stephen Serpe, Marcelo Martinez, Peggy Buerki, Sven Int J Mol Sci Article Severe drought conditions and extreme weather events are increasing worldwide with climate change, threatening the persistence of native plant communities and ecosystems. Many studies have investigated the genomic basis of plant responses to drought. However, the extent of this research throughout the plant kingdom is unclear, particularly among species critical for the sustainability of natural ecosystems. This study aimed to broaden our understanding of genome-to-phenome (G2P) connections in drought-stressed plants and identify focal taxa for future research. Bioinformatics pipelines were developed to mine and link information from databases and abstracts from 7730 publications. This approach identified 1634 genes involved in drought responses among 497 plant taxa. Most (83.30%) of these species have been classified for human use, and most G2P interactions have been described within model organisms or crop species. Our analysis identifies several gaps in G2P research literature and database connectivity, with 21% of abstracts being linked to gene and taxonomy data in NCBI. Abstract text mining was more successful at identifying potential G2P pathways, with 34% of abstracts containing gene, taxa, and phenotype information. Expanding G2P studies to include non-model plants, especially those that are adapted to drought stress, will help advance our understanding of drought responsive G2P pathways. MDPI 2022-10-14 /pmc/articles/PMC9602940/ /pubmed/36293161 http://dx.doi.org/10.3390/ijms232012297 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Melton, Anthony E.
Galla, Stephanie J.
Dumaguit, Carlos Dave C.
Wojahn, John M. A.
Novak, Stephen
Serpe, Marcelo
Martinez, Peggy
Buerki, Sven
Meta-Analysis Reveals Challenges and Gaps for Genome-to-Phenome Research Underpinning Plant Drought Response
title Meta-Analysis Reveals Challenges and Gaps for Genome-to-Phenome Research Underpinning Plant Drought Response
title_full Meta-Analysis Reveals Challenges and Gaps for Genome-to-Phenome Research Underpinning Plant Drought Response
title_fullStr Meta-Analysis Reveals Challenges and Gaps for Genome-to-Phenome Research Underpinning Plant Drought Response
title_full_unstemmed Meta-Analysis Reveals Challenges and Gaps for Genome-to-Phenome Research Underpinning Plant Drought Response
title_short Meta-Analysis Reveals Challenges and Gaps for Genome-to-Phenome Research Underpinning Plant Drought Response
title_sort meta-analysis reveals challenges and gaps for genome-to-phenome research underpinning plant drought response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602940/
https://www.ncbi.nlm.nih.gov/pubmed/36293161
http://dx.doi.org/10.3390/ijms232012297
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