Preferential Selection of Low-Frequency, Lipopolysaccharide-Modified, Colistin-Resistant Mutants with a Combination of Antimicrobials in Acinetobacter baumannii

Colistin, which targets lipopolysaccharide (LPS), is used as a last-resort drug against severe infections caused by drug-resistant Acinetobacter baumannii. However, A. baumannii possesses two colistin-resistance mechanisms. LPS modification caused by mutations in pmrAB genes is often observed in cli...

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Detalles Bibliográficos
Autores principales: Kamoshida, Go, Yamada, Noriteru, Nakamura, Tomoka, Yamaguchi, Daiki, Kai, Daichi, Yamashita, Maho, Hayashi, Chiaki, Kanda, Nana, Sakaguchi, Moe, Morimoto, Hitoshi, Sawada, Teppei, Okada, Tomoko, Kaya, Yuki, Takemoto, Norihiko, Yahiro, Kinnosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602988/
https://www.ncbi.nlm.nih.gov/pubmed/36173297
http://dx.doi.org/10.1128/spectrum.01928-22

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