Dual-Reporter System for Real-Time Monitoring of SARS-CoV-2 Main Protease Activity in Live Cells Enables Identification of an Allosteric Inhibition Path

[Image: see text] The SARS-CoV-2 pandemic is an ongoing threat to global health, and the continuing emergence of contagious variants highlights the urgent need for additional antiviral therapy to attenuate COVID-19 disease. The SARS-CoV-2 main protease (3CL(pro)) presents an attractive target for su...

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Detalles Bibliográficos
Autores principales: Bram, Yaron, Duan, Xiaohua, Nilsson-Payant, Benjamin E., Chandar, Vasuretha, Wu, Hao, Shore, Derek, Fajardo, Alvaro, Sinha, Saloni, Hassan, Nora, Weinstein, Harel, TenOever, Benjamin R., Chen, Shuibing, Schwartz, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603010/
https://www.ncbi.nlm.nih.gov/pubmed/36570071
http://dx.doi.org/10.1021/acsbiomedchemau.2c00034

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