Cargando…

Examining the Associations between Post-Stroke Cognitive Function and Common Comorbid Conditions among Stroke Survivors

A considerable complication for stroke survivors is the subsequent development of cognitive decline or dementia. In this study, the relationship between the inflammation-centered comorbidity burden on post-stroke cognitive function among community-dwelling stroke survivors capable of independent liv...

Descripción completa

Detalles Bibliográficos
Autores principales: Morrison, Helena W., White, Melissa M., Rothers, Janet L., Taylor-Piliae, Ruth E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603222/
https://www.ncbi.nlm.nih.gov/pubmed/36294026
http://dx.doi.org/10.3390/ijerph192013445
_version_ 1784817495322918912
author Morrison, Helena W.
White, Melissa M.
Rothers, Janet L.
Taylor-Piliae, Ruth E.
author_facet Morrison, Helena W.
White, Melissa M.
Rothers, Janet L.
Taylor-Piliae, Ruth E.
author_sort Morrison, Helena W.
collection PubMed
description A considerable complication for stroke survivors is the subsequent development of cognitive decline or dementia. In this study, the relationship between the inflammation-centered comorbidity burden on post-stroke cognitive function among community-dwelling stroke survivors capable of independent living was examined. Data for this secondary analysis were collected from stroke survivors (n = 97) participating in a randomized clinical trial. Participants provided baseline responses, regarding cognitive function (mini-mental status exam, MMSE; Montreal cognitive assessment, MoCA), history of stroke comorbid conditions, and the Stroke Prognosis Instrument-II (SPI-II), an index of stroke comorbidity and recurrent stroke risk within the next two years. Relationships and differences between groups were tested for significance using Spearman’s correlation, Kruskal–Wallis, or Mann–Whitney U tests. Most stroke survivors (69%) had multiple comorbidities. Total SPI-II scores were negatively correlated to both MoCA and MMSE scores (r = −0.25, p = 0.01; r = −0.22, p = 0.03, respectively), and differences in MoCA scores among SPI-II risk groups (low, medium, high) were evident (p = 0.05). In contrast, there were no differences in MoCA or MMSE scores when comorbid conditions were examined individually. Lastly, no gender differences were evident in cognitive assessments. Our data support the premise that comorbidity’s burden impacts post-stroke cognitive decline, more than a single comorbid condition. Inflammation may be an important component of this comorbidity burden. Future studies that operationalize this concept will better illuminate the complex phenomenon of post-stroke cognitive decline for improved clinical rehabilitation modalities.
format Online
Article
Text
id pubmed-9603222
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96032222022-10-27 Examining the Associations between Post-Stroke Cognitive Function and Common Comorbid Conditions among Stroke Survivors Morrison, Helena W. White, Melissa M. Rothers, Janet L. Taylor-Piliae, Ruth E. Int J Environ Res Public Health Article A considerable complication for stroke survivors is the subsequent development of cognitive decline or dementia. In this study, the relationship between the inflammation-centered comorbidity burden on post-stroke cognitive function among community-dwelling stroke survivors capable of independent living was examined. Data for this secondary analysis were collected from stroke survivors (n = 97) participating in a randomized clinical trial. Participants provided baseline responses, regarding cognitive function (mini-mental status exam, MMSE; Montreal cognitive assessment, MoCA), history of stroke comorbid conditions, and the Stroke Prognosis Instrument-II (SPI-II), an index of stroke comorbidity and recurrent stroke risk within the next two years. Relationships and differences between groups were tested for significance using Spearman’s correlation, Kruskal–Wallis, or Mann–Whitney U tests. Most stroke survivors (69%) had multiple comorbidities. Total SPI-II scores were negatively correlated to both MoCA and MMSE scores (r = −0.25, p = 0.01; r = −0.22, p = 0.03, respectively), and differences in MoCA scores among SPI-II risk groups (low, medium, high) were evident (p = 0.05). In contrast, there were no differences in MoCA or MMSE scores when comorbid conditions were examined individually. Lastly, no gender differences were evident in cognitive assessments. Our data support the premise that comorbidity’s burden impacts post-stroke cognitive decline, more than a single comorbid condition. Inflammation may be an important component of this comorbidity burden. Future studies that operationalize this concept will better illuminate the complex phenomenon of post-stroke cognitive decline for improved clinical rehabilitation modalities. MDPI 2022-10-18 /pmc/articles/PMC9603222/ /pubmed/36294026 http://dx.doi.org/10.3390/ijerph192013445 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Morrison, Helena W.
White, Melissa M.
Rothers, Janet L.
Taylor-Piliae, Ruth E.
Examining the Associations between Post-Stroke Cognitive Function and Common Comorbid Conditions among Stroke Survivors
title Examining the Associations between Post-Stroke Cognitive Function and Common Comorbid Conditions among Stroke Survivors
title_full Examining the Associations between Post-Stroke Cognitive Function and Common Comorbid Conditions among Stroke Survivors
title_fullStr Examining the Associations between Post-Stroke Cognitive Function and Common Comorbid Conditions among Stroke Survivors
title_full_unstemmed Examining the Associations between Post-Stroke Cognitive Function and Common Comorbid Conditions among Stroke Survivors
title_short Examining the Associations between Post-Stroke Cognitive Function and Common Comorbid Conditions among Stroke Survivors
title_sort examining the associations between post-stroke cognitive function and common comorbid conditions among stroke survivors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603222/
https://www.ncbi.nlm.nih.gov/pubmed/36294026
http://dx.doi.org/10.3390/ijerph192013445
work_keys_str_mv AT morrisonhelenaw examiningtheassociationsbetweenpoststrokecognitivefunctionandcommoncomorbidconditionsamongstrokesurvivors
AT whitemelissam examiningtheassociationsbetweenpoststrokecognitivefunctionandcommoncomorbidconditionsamongstrokesurvivors
AT rothersjanetl examiningtheassociationsbetweenpoststrokecognitivefunctionandcommoncomorbidconditionsamongstrokesurvivors
AT taylorpiliaeruthe examiningtheassociationsbetweenpoststrokecognitivefunctionandcommoncomorbidconditionsamongstrokesurvivors