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Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia

Albeit multiple studies demonstrated that vasa vasorum (VV) have a crucial importance in vascular pathology, the informative markers and metrics of vascular inflammation defining the development of intimal hyperplasia (IH) have been vaguely studied. Here, we employed two rat models (balloon injury o...

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Autores principales: Bogdanov, Leo, Shishkova, Daria, Mukhamadiyarov, Rinat, Velikanova, Elena, Tsepokina, Anna, Terekhov, Alexander, Koshelev, Vladislav, Kanonykina, Anastasia, Shabaev, Amin, Frolov, Alexey, Zagorodnikov, Nikita, Kutikhin, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603343/
https://www.ncbi.nlm.nih.gov/pubmed/36293013
http://dx.doi.org/10.3390/ijms232012156
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author Bogdanov, Leo
Shishkova, Daria
Mukhamadiyarov, Rinat
Velikanova, Elena
Tsepokina, Anna
Terekhov, Alexander
Koshelev, Vladislav
Kanonykina, Anastasia
Shabaev, Amin
Frolov, Alexey
Zagorodnikov, Nikita
Kutikhin, Anton
author_facet Bogdanov, Leo
Shishkova, Daria
Mukhamadiyarov, Rinat
Velikanova, Elena
Tsepokina, Anna
Terekhov, Alexander
Koshelev, Vladislav
Kanonykina, Anastasia
Shabaev, Amin
Frolov, Alexey
Zagorodnikov, Nikita
Kutikhin, Anton
author_sort Bogdanov, Leo
collection PubMed
description Albeit multiple studies demonstrated that vasa vasorum (VV) have a crucial importance in vascular pathology, the informative markers and metrics of vascular inflammation defining the development of intimal hyperplasia (IH) have been vaguely studied. Here, we employed two rat models (balloon injury of the abdominal aorta and the same intervention optionally complemented with intravenous injections of calciprotein particles) and a clinical scenario (arterial and venous conduits for coronary artery bypass graft (CABG) surgery) to investigate the pathophysiological interconnections among VV, myeloperoxidase-positive (MPO(+)) clusters, and IH. We found that the amounts of VV and MPO(+) clusters were strongly correlated; further, MPO(+) clusters density was significantly associated with balloon-induced IH and increased at calciprotein particle-provoked endothelial dysfunction. Likewise, number and density of VV correlated with IH in bypass grafts for CABG surgery at the pre-intervention stage and were higher in venous conduits which more frequently suffered from IH as compared with arterial grafts. Collectively, our results underline the pathophysiological importance of excessive VV upon the vascular injury or at the exposure to cardiovascular risk factors, highlight MPO(+) clusters as an informative marker of adventitial and perivascular inflammation, and propose another mechanistic explanation of a higher long-term patency of arterial grafts upon the CABG surgery.
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spelling pubmed-96033432022-10-27 Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia Bogdanov, Leo Shishkova, Daria Mukhamadiyarov, Rinat Velikanova, Elena Tsepokina, Anna Terekhov, Alexander Koshelev, Vladislav Kanonykina, Anastasia Shabaev, Amin Frolov, Alexey Zagorodnikov, Nikita Kutikhin, Anton Int J Mol Sci Article Albeit multiple studies demonstrated that vasa vasorum (VV) have a crucial importance in vascular pathology, the informative markers and metrics of vascular inflammation defining the development of intimal hyperplasia (IH) have been vaguely studied. Here, we employed two rat models (balloon injury of the abdominal aorta and the same intervention optionally complemented with intravenous injections of calciprotein particles) and a clinical scenario (arterial and venous conduits for coronary artery bypass graft (CABG) surgery) to investigate the pathophysiological interconnections among VV, myeloperoxidase-positive (MPO(+)) clusters, and IH. We found that the amounts of VV and MPO(+) clusters were strongly correlated; further, MPO(+) clusters density was significantly associated with balloon-induced IH and increased at calciprotein particle-provoked endothelial dysfunction. Likewise, number and density of VV correlated with IH in bypass grafts for CABG surgery at the pre-intervention stage and were higher in venous conduits which more frequently suffered from IH as compared with arterial grafts. Collectively, our results underline the pathophysiological importance of excessive VV upon the vascular injury or at the exposure to cardiovascular risk factors, highlight MPO(+) clusters as an informative marker of adventitial and perivascular inflammation, and propose another mechanistic explanation of a higher long-term patency of arterial grafts upon the CABG surgery. MDPI 2022-10-12 /pmc/articles/PMC9603343/ /pubmed/36293013 http://dx.doi.org/10.3390/ijms232012156 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bogdanov, Leo
Shishkova, Daria
Mukhamadiyarov, Rinat
Velikanova, Elena
Tsepokina, Anna
Terekhov, Alexander
Koshelev, Vladislav
Kanonykina, Anastasia
Shabaev, Amin
Frolov, Alexey
Zagorodnikov, Nikita
Kutikhin, Anton
Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia
title Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia
title_full Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia
title_fullStr Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia
title_full_unstemmed Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia
title_short Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia
title_sort excessive adventitial and perivascular vascularisation correlates with vascular inflammation and intimal hyperplasia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603343/
https://www.ncbi.nlm.nih.gov/pubmed/36293013
http://dx.doi.org/10.3390/ijms232012156
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