A High Daptomycin Dose Is Associated with Better Bacterial Clearance in Infections Caused by Vancomycin-Resistant Enterococcus faecium Regardless of Daptomycin Minimum Inhibitory Concentration in a Rat Infective Endocarditis Model

A high daptomycin dose has been suggested for treating vancomycin-resistant Enterococcus faecium (VREf) infections. However, even a 12 mg/kg daptomycin dose might be insufficient for treating VREf with high daptomycin minimum inhibitory concentrations (MICs). Additionally, animal pharmacodynamic and...

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Detalles Bibliográficos
Autores principales: Wang, Jann-Tay, Yang, Chia-Jui, Yang, Jia-Ling, Lin, Shu-Wen, Chuang, Yu-Chung, Sheng, Wang-Huei, Chen, Yee-Chun, Chang, Shan-Chwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603373/
https://www.ncbi.nlm.nih.gov/pubmed/36190402
http://dx.doi.org/10.1128/spectrum.02551-22

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