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Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition

Serine palmitoyltransferase catalyzes the first step of the sphingolipid biosynthesis. Recently, sphingolipid homeostasis has been connected to several human diseases, making serine palmitoyltransferases an interesting therapeutic target. Known and efficient serine palmitoyltransferase-inhibitors ar...

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Detalles Bibliográficos
Autores principales:	Hoefgen, Sandra, Bissell, Alexander U., Huang, Ying, Gherlone, Fabio, Raguž, Luka, Beemelmanns, Christine, Valiante, Vito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603476/ https://www.ncbi.nlm.nih.gov/pubmed/36121228 http://dx.doi.org/10.1128/spectrum.01331-22

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