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Changes in Tear Proteomic Profile in Ocular Diseases

The search for proteomic biomarkers in ocular disease is one of the most important research directions in recent years. Reliable biomarkers can be an immense adjuvant for both diagnostic and therapeutic approaches. There is no more readily available ocular tissue for proteomic analysis than tear fil...

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Detalles Bibliográficos
Autores principales: Winiarczyk, Mateusz, Biela, Katarzyna, Michalak, Katarzyna, Winiarczyk, Dagmara, Mackiewicz, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603516/
https://www.ncbi.nlm.nih.gov/pubmed/36293921
http://dx.doi.org/10.3390/ijerph192013341
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author Winiarczyk, Mateusz
Biela, Katarzyna
Michalak, Katarzyna
Winiarczyk, Dagmara
Mackiewicz, Jerzy
author_facet Winiarczyk, Mateusz
Biela, Katarzyna
Michalak, Katarzyna
Winiarczyk, Dagmara
Mackiewicz, Jerzy
author_sort Winiarczyk, Mateusz
collection PubMed
description The search for proteomic biomarkers in ocular disease is one of the most important research directions in recent years. Reliable biomarkers can be an immense adjuvant for both diagnostic and therapeutic approaches. There is no more readily available ocular tissue for proteomic analysis than tear film, which makes an interesting target for the biomarker search. Tear film is a complex fluid consisting of a superficial lipid layer, which covers the aqueous-mucous layer. Its complexity makes it a perfect candidate for all the “omics” approaches. Glaucoma, cataract, age-related macular degeneration, and other diseases are commonly thought to have a multifactorial background. Currently, no reliable non-invasive tests are available that would help physicians with screening and further patient management. The aim of the study is to present modern methods of measuring biomarkers in tears, with particular emphasis on spectrometric methods, and to discuss their diagnostic and therapeutic usefulness.
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spelling pubmed-96035162022-10-27 Changes in Tear Proteomic Profile in Ocular Diseases Winiarczyk, Mateusz Biela, Katarzyna Michalak, Katarzyna Winiarczyk, Dagmara Mackiewicz, Jerzy Int J Environ Res Public Health Review The search for proteomic biomarkers in ocular disease is one of the most important research directions in recent years. Reliable biomarkers can be an immense adjuvant for both diagnostic and therapeutic approaches. There is no more readily available ocular tissue for proteomic analysis than tear film, which makes an interesting target for the biomarker search. Tear film is a complex fluid consisting of a superficial lipid layer, which covers the aqueous-mucous layer. Its complexity makes it a perfect candidate for all the “omics” approaches. Glaucoma, cataract, age-related macular degeneration, and other diseases are commonly thought to have a multifactorial background. Currently, no reliable non-invasive tests are available that would help physicians with screening and further patient management. The aim of the study is to present modern methods of measuring biomarkers in tears, with particular emphasis on spectrometric methods, and to discuss their diagnostic and therapeutic usefulness. MDPI 2022-10-16 /pmc/articles/PMC9603516/ /pubmed/36293921 http://dx.doi.org/10.3390/ijerph192013341 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Winiarczyk, Mateusz
Biela, Katarzyna
Michalak, Katarzyna
Winiarczyk, Dagmara
Mackiewicz, Jerzy
Changes in Tear Proteomic Profile in Ocular Diseases
title Changes in Tear Proteomic Profile in Ocular Diseases
title_full Changes in Tear Proteomic Profile in Ocular Diseases
title_fullStr Changes in Tear Proteomic Profile in Ocular Diseases
title_full_unstemmed Changes in Tear Proteomic Profile in Ocular Diseases
title_short Changes in Tear Proteomic Profile in Ocular Diseases
title_sort changes in tear proteomic profile in ocular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603516/
https://www.ncbi.nlm.nih.gov/pubmed/36293921
http://dx.doi.org/10.3390/ijerph192013341
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