Cargando…
Changes in Tear Proteomic Profile in Ocular Diseases
The search for proteomic biomarkers in ocular disease is one of the most important research directions in recent years. Reliable biomarkers can be an immense adjuvant for both diagnostic and therapeutic approaches. There is no more readily available ocular tissue for proteomic analysis than tear fil...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603516/ https://www.ncbi.nlm.nih.gov/pubmed/36293921 http://dx.doi.org/10.3390/ijerph192013341 |
_version_ | 1784817570316025856 |
---|---|
author | Winiarczyk, Mateusz Biela, Katarzyna Michalak, Katarzyna Winiarczyk, Dagmara Mackiewicz, Jerzy |
author_facet | Winiarczyk, Mateusz Biela, Katarzyna Michalak, Katarzyna Winiarczyk, Dagmara Mackiewicz, Jerzy |
author_sort | Winiarczyk, Mateusz |
collection | PubMed |
description | The search for proteomic biomarkers in ocular disease is one of the most important research directions in recent years. Reliable biomarkers can be an immense adjuvant for both diagnostic and therapeutic approaches. There is no more readily available ocular tissue for proteomic analysis than tear film, which makes an interesting target for the biomarker search. Tear film is a complex fluid consisting of a superficial lipid layer, which covers the aqueous-mucous layer. Its complexity makes it a perfect candidate for all the “omics” approaches. Glaucoma, cataract, age-related macular degeneration, and other diseases are commonly thought to have a multifactorial background. Currently, no reliable non-invasive tests are available that would help physicians with screening and further patient management. The aim of the study is to present modern methods of measuring biomarkers in tears, with particular emphasis on spectrometric methods, and to discuss their diagnostic and therapeutic usefulness. |
format | Online Article Text |
id | pubmed-9603516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96035162022-10-27 Changes in Tear Proteomic Profile in Ocular Diseases Winiarczyk, Mateusz Biela, Katarzyna Michalak, Katarzyna Winiarczyk, Dagmara Mackiewicz, Jerzy Int J Environ Res Public Health Review The search for proteomic biomarkers in ocular disease is one of the most important research directions in recent years. Reliable biomarkers can be an immense adjuvant for both diagnostic and therapeutic approaches. There is no more readily available ocular tissue for proteomic analysis than tear film, which makes an interesting target for the biomarker search. Tear film is a complex fluid consisting of a superficial lipid layer, which covers the aqueous-mucous layer. Its complexity makes it a perfect candidate for all the “omics” approaches. Glaucoma, cataract, age-related macular degeneration, and other diseases are commonly thought to have a multifactorial background. Currently, no reliable non-invasive tests are available that would help physicians with screening and further patient management. The aim of the study is to present modern methods of measuring biomarkers in tears, with particular emphasis on spectrometric methods, and to discuss their diagnostic and therapeutic usefulness. MDPI 2022-10-16 /pmc/articles/PMC9603516/ /pubmed/36293921 http://dx.doi.org/10.3390/ijerph192013341 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Winiarczyk, Mateusz Biela, Katarzyna Michalak, Katarzyna Winiarczyk, Dagmara Mackiewicz, Jerzy Changes in Tear Proteomic Profile in Ocular Diseases |
title | Changes in Tear Proteomic Profile in Ocular Diseases |
title_full | Changes in Tear Proteomic Profile in Ocular Diseases |
title_fullStr | Changes in Tear Proteomic Profile in Ocular Diseases |
title_full_unstemmed | Changes in Tear Proteomic Profile in Ocular Diseases |
title_short | Changes in Tear Proteomic Profile in Ocular Diseases |
title_sort | changes in tear proteomic profile in ocular diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603516/ https://www.ncbi.nlm.nih.gov/pubmed/36293921 http://dx.doi.org/10.3390/ijerph192013341 |
work_keys_str_mv | AT winiarczykmateusz changesintearproteomicprofileinoculardiseases AT bielakatarzyna changesintearproteomicprofileinoculardiseases AT michalakkatarzyna changesintearproteomicprofileinoculardiseases AT winiarczykdagmara changesintearproteomicprofileinoculardiseases AT mackiewiczjerzy changesintearproteomicprofileinoculardiseases |