Wnt Signaling and Aging of the Gastrointestinal Tract

Aging is considered a risk factor for various diseases including cancers. In this aging society, there is an urgent need to clarify the molecular mechanisms involved in aging. Wnt signaling has been shown to play a crucial role in the maintenance and differentiation of tissue stem cells, and intensi...

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Autores principales: Asano, Naoki, Takeuchi, Akio, Imatani, Akira, Saito, Masashi, Jin, Xiaoyi, Hatta, Waku, Uno, Kaname, Koike, Tomoyuki, Masamune, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603545/
https://www.ncbi.nlm.nih.gov/pubmed/36293064
http://dx.doi.org/10.3390/ijms232012210
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author Asano, Naoki
Takeuchi, Akio
Imatani, Akira
Saito, Masashi
Jin, Xiaoyi
Hatta, Waku
Uno, Kaname
Koike, Tomoyuki
Masamune, Atsushi
author_facet Asano, Naoki
Takeuchi, Akio
Imatani, Akira
Saito, Masashi
Jin, Xiaoyi
Hatta, Waku
Uno, Kaname
Koike, Tomoyuki
Masamune, Atsushi
author_sort Asano, Naoki
collection PubMed
description Aging is considered a risk factor for various diseases including cancers. In this aging society, there is an urgent need to clarify the molecular mechanisms involved in aging. Wnt signaling has been shown to play a crucial role in the maintenance and differentiation of tissue stem cells, and intensive studies have elucidated its pivotal role in the aging of neural and muscle stem cells. However, until recently, such studies on the gastrointestinal tract have been limited. In this review, we discuss recent advances in the study of the role of Wnt signaling in the aging of the gastrointestinal tract and aging-related carcinogenesis.
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spelling pubmed-96035452022-10-27 Wnt Signaling and Aging of the Gastrointestinal Tract Asano, Naoki Takeuchi, Akio Imatani, Akira Saito, Masashi Jin, Xiaoyi Hatta, Waku Uno, Kaname Koike, Tomoyuki Masamune, Atsushi Int J Mol Sci Review Aging is considered a risk factor for various diseases including cancers. In this aging society, there is an urgent need to clarify the molecular mechanisms involved in aging. Wnt signaling has been shown to play a crucial role in the maintenance and differentiation of tissue stem cells, and intensive studies have elucidated its pivotal role in the aging of neural and muscle stem cells. However, until recently, such studies on the gastrointestinal tract have been limited. In this review, we discuss recent advances in the study of the role of Wnt signaling in the aging of the gastrointestinal tract and aging-related carcinogenesis. MDPI 2022-10-13 /pmc/articles/PMC9603545/ /pubmed/36293064 http://dx.doi.org/10.3390/ijms232012210 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Asano, Naoki
Takeuchi, Akio
Imatani, Akira
Saito, Masashi
Jin, Xiaoyi
Hatta, Waku
Uno, Kaname
Koike, Tomoyuki
Masamune, Atsushi
Wnt Signaling and Aging of the Gastrointestinal Tract
title Wnt Signaling and Aging of the Gastrointestinal Tract
title_full Wnt Signaling and Aging of the Gastrointestinal Tract
title_fullStr Wnt Signaling and Aging of the Gastrointestinal Tract
title_full_unstemmed Wnt Signaling and Aging of the Gastrointestinal Tract
title_short Wnt Signaling and Aging of the Gastrointestinal Tract
title_sort wnt signaling and aging of the gastrointestinal tract
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603545/
https://www.ncbi.nlm.nih.gov/pubmed/36293064
http://dx.doi.org/10.3390/ijms232012210
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