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SARS-CoV-2 Vaccines and Adverse Effects in Gynecology and Obstetrics: The First Italian Retrospective Study

The most common effects reported by the Italian Medicine Agency following administration of SARS-CoV-2 vaccine are myalgia, soreness to the arm of inoculation, fever, and asthenia. To date, there are no specific and official reports registered by the Italian Medicine Agency on possible alterations o...

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Autores principales: Dellino, Miriam, Lamanna, Bruno, Vinciguerra, Marina, Tafuri, Silvio, Stefanizzi, Pasquale, Malvasi, Antonio, Di Vagno, Giovanni, Cormio, Gennaro, Loizzi, Vera, Cazzato, Gerardo, Tinelli, Raffaele, Cicinelli, Ettore, Pinto, Vincenzo, Daniele, Antonella, Maiorano, Eugenio, Resta, Leonardo, De Vito, Danila, Scacco, Salvatore, Cascardi, Eliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603573/
https://www.ncbi.nlm.nih.gov/pubmed/36293746
http://dx.doi.org/10.3390/ijerph192013167
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author Dellino, Miriam
Lamanna, Bruno
Vinciguerra, Marina
Tafuri, Silvio
Stefanizzi, Pasquale
Malvasi, Antonio
Di Vagno, Giovanni
Cormio, Gennaro
Loizzi, Vera
Cazzato, Gerardo
Tinelli, Raffaele
Cicinelli, Ettore
Pinto, Vincenzo
Daniele, Antonella
Maiorano, Eugenio
Resta, Leonardo
De Vito, Danila
Scacco, Salvatore
Cascardi, Eliano
author_facet Dellino, Miriam
Lamanna, Bruno
Vinciguerra, Marina
Tafuri, Silvio
Stefanizzi, Pasquale
Malvasi, Antonio
Di Vagno, Giovanni
Cormio, Gennaro
Loizzi, Vera
Cazzato, Gerardo
Tinelli, Raffaele
Cicinelli, Ettore
Pinto, Vincenzo
Daniele, Antonella
Maiorano, Eugenio
Resta, Leonardo
De Vito, Danila
Scacco, Salvatore
Cascardi, Eliano
author_sort Dellino, Miriam
collection PubMed
description The most common effects reported by the Italian Medicine Agency following administration of SARS-CoV-2 vaccine are myalgia, soreness to the arm of inoculation, fever, and asthenia. To date, there are no specific and official reports registered by the Italian Medicine Agency on possible alterations of the menstrual cycle, or of the female reproductive system, following the vaccine. Actually, clinical experience showed a spread of transient adverse drug reactions of the menstrual cycle, following the administration of all COVID-19 vaccine types, both mRNA and Adenovirus vectored ones. In this work, we conducted the first retrospective study on Italian patients vaccinated for SARS-CoV-2 in the period between April 2021 and April 2022, to report the onset of menstrual changes after the vaccine in order to understand: etiology, duration of possible adverse effects, and the extent of the phenomenon. We recruited 100 women aged 18–45, vaccinated for SARS-CoV-2, who were asked to complete a questionnaire consisting of 12 multiple choice questions about the effects of the vaccine on the reproductive system. Thirty-seven of them received three doses of the vaccine, while the remaining 63 received two doses. Symptoms such as delayed menstruation and abnormal uterine bleeding (metrorrhagia, menometrorrhagia, and menorrhagia) were generally reported within the first three weeks of vaccination, especially after the second dose, with a percentage of 23% and 77%, respectively. These preliminary data suggest that this problem may be broader and deserving of further investigation in the future.
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spelling pubmed-96035732022-10-27 SARS-CoV-2 Vaccines and Adverse Effects in Gynecology and Obstetrics: The First Italian Retrospective Study Dellino, Miriam Lamanna, Bruno Vinciguerra, Marina Tafuri, Silvio Stefanizzi, Pasquale Malvasi, Antonio Di Vagno, Giovanni Cormio, Gennaro Loizzi, Vera Cazzato, Gerardo Tinelli, Raffaele Cicinelli, Ettore Pinto, Vincenzo Daniele, Antonella Maiorano, Eugenio Resta, Leonardo De Vito, Danila Scacco, Salvatore Cascardi, Eliano Int J Environ Res Public Health Article The most common effects reported by the Italian Medicine Agency following administration of SARS-CoV-2 vaccine are myalgia, soreness to the arm of inoculation, fever, and asthenia. To date, there are no specific and official reports registered by the Italian Medicine Agency on possible alterations of the menstrual cycle, or of the female reproductive system, following the vaccine. Actually, clinical experience showed a spread of transient adverse drug reactions of the menstrual cycle, following the administration of all COVID-19 vaccine types, both mRNA and Adenovirus vectored ones. In this work, we conducted the first retrospective study on Italian patients vaccinated for SARS-CoV-2 in the period between April 2021 and April 2022, to report the onset of menstrual changes after the vaccine in order to understand: etiology, duration of possible adverse effects, and the extent of the phenomenon. We recruited 100 women aged 18–45, vaccinated for SARS-CoV-2, who were asked to complete a questionnaire consisting of 12 multiple choice questions about the effects of the vaccine on the reproductive system. Thirty-seven of them received three doses of the vaccine, while the remaining 63 received two doses. Symptoms such as delayed menstruation and abnormal uterine bleeding (metrorrhagia, menometrorrhagia, and menorrhagia) were generally reported within the first three weeks of vaccination, especially after the second dose, with a percentage of 23% and 77%, respectively. These preliminary data suggest that this problem may be broader and deserving of further investigation in the future. MDPI 2022-10-13 /pmc/articles/PMC9603573/ /pubmed/36293746 http://dx.doi.org/10.3390/ijerph192013167 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dellino, Miriam
Lamanna, Bruno
Vinciguerra, Marina
Tafuri, Silvio
Stefanizzi, Pasquale
Malvasi, Antonio
Di Vagno, Giovanni
Cormio, Gennaro
Loizzi, Vera
Cazzato, Gerardo
Tinelli, Raffaele
Cicinelli, Ettore
Pinto, Vincenzo
Daniele, Antonella
Maiorano, Eugenio
Resta, Leonardo
De Vito, Danila
Scacco, Salvatore
Cascardi, Eliano
SARS-CoV-2 Vaccines and Adverse Effects in Gynecology and Obstetrics: The First Italian Retrospective Study
title SARS-CoV-2 Vaccines and Adverse Effects in Gynecology and Obstetrics: The First Italian Retrospective Study
title_full SARS-CoV-2 Vaccines and Adverse Effects in Gynecology and Obstetrics: The First Italian Retrospective Study
title_fullStr SARS-CoV-2 Vaccines and Adverse Effects in Gynecology and Obstetrics: The First Italian Retrospective Study
title_full_unstemmed SARS-CoV-2 Vaccines and Adverse Effects in Gynecology and Obstetrics: The First Italian Retrospective Study
title_short SARS-CoV-2 Vaccines and Adverse Effects in Gynecology and Obstetrics: The First Italian Retrospective Study
title_sort sars-cov-2 vaccines and adverse effects in gynecology and obstetrics: the first italian retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603573/
https://www.ncbi.nlm.nih.gov/pubmed/36293746
http://dx.doi.org/10.3390/ijerph192013167
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