Comprehensive In Silico Functional Prediction Analysis of CDKL5 by Single Amino Acid Substitution in the Catalytic Domain

Cyclin-dependent kinase-like 5 (CDKL5) is a serine/threonine protein kinase whose pathological mutations cause CDKL5 deficiency disorder. Most missense mutations are concentrated in the catalytic domain. Therefore, anticipating whether mutations in this region affect CDKL5 function is informative fo...

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Detalles Bibliográficos
Autores principales: Yoshimura, Yuri, Morii, Atsushi, Fujino, Yuuki, Nagase, Marina, Kitano, Arisa, Ueno, Shiho, Takeuchi, Kyoka, Yamashita, Riko, Inazu, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603577/
https://www.ncbi.nlm.nih.gov/pubmed/36293137
http://dx.doi.org/10.3390/ijms232012281

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