Fitness Trade-Offs in Phage Cocktail-Resistant Salmonella enterica Serovar Enteritidis Results in Increased Antibiotic Susceptibility and Reduced Virulence

The rapid emergence of phage-resistant bacterial mutants is a major challenge for phage therapy. Phage cocktails have been considered one approach to mitigate this issue. However, the synergistic effect of randomly selected phages in the cocktails is ambiguous. Here, we rationally designed a phage c...

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Detalles Bibliográficos
Autores principales: Gao, Dongyang, Ji, Hongyue, Wang, Linkang, Li, Xinxin, Hu, Dayue, Zhao, Junna, Wang, Shuang, Tao, Pan, Li, Xiangmin, Qian, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603643/
https://www.ncbi.nlm.nih.gov/pubmed/36165776
http://dx.doi.org/10.1128/spectrum.02914-22

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