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Chitin Synthesis in Yeast: A Matter of Trafficking

Chitin synthesis has attracted scientific interest for decades as an essential part of fungal biology and for its potential as a target for antifungal therapies. While this interest remains, three decades ago, pioneering molecular studies on chitin synthesis regulation identified the major chitin sy...

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Detalles Bibliográficos
Autores principales: Sánchez, Noelia, Roncero, César
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603707/
https://www.ncbi.nlm.nih.gov/pubmed/36293107
http://dx.doi.org/10.3390/ijms232012251
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author Sánchez, Noelia
Roncero, César
author_facet Sánchez, Noelia
Roncero, César
author_sort Sánchez, Noelia
collection PubMed
description Chitin synthesis has attracted scientific interest for decades as an essential part of fungal biology and for its potential as a target for antifungal therapies. While this interest remains, three decades ago, pioneering molecular studies on chitin synthesis regulation identified the major chitin synthase in yeast, Chs3, as an authentic paradigm in the field of the intracellular trafficking of integral membrane proteins. Over the years, researchers have shown how the intracellular trafficking of Chs3 recapitulates all the steps in the intracellular trafficking of integral membrane proteins, from their synthesis in the endoplasmic reticulum to their degradation in the vacuole. This trafficking includes specific mechanisms for sorting in the trans-Golgi network, regulated endocytosis, and endosomal recycling at different levels. This review summarizes the work carried out on chitin synthesis regulation, mostly focusing on Chs3 as a molecular model to study the mechanisms involved in the control of the intracellular trafficking of proteins.
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spelling pubmed-96037072022-10-27 Chitin Synthesis in Yeast: A Matter of Trafficking Sánchez, Noelia Roncero, César Int J Mol Sci Review Chitin synthesis has attracted scientific interest for decades as an essential part of fungal biology and for its potential as a target for antifungal therapies. While this interest remains, three decades ago, pioneering molecular studies on chitin synthesis regulation identified the major chitin synthase in yeast, Chs3, as an authentic paradigm in the field of the intracellular trafficking of integral membrane proteins. Over the years, researchers have shown how the intracellular trafficking of Chs3 recapitulates all the steps in the intracellular trafficking of integral membrane proteins, from their synthesis in the endoplasmic reticulum to their degradation in the vacuole. This trafficking includes specific mechanisms for sorting in the trans-Golgi network, regulated endocytosis, and endosomal recycling at different levels. This review summarizes the work carried out on chitin synthesis regulation, mostly focusing on Chs3 as a molecular model to study the mechanisms involved in the control of the intracellular trafficking of proteins. MDPI 2022-10-14 /pmc/articles/PMC9603707/ /pubmed/36293107 http://dx.doi.org/10.3390/ijms232012251 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sánchez, Noelia
Roncero, César
Chitin Synthesis in Yeast: A Matter of Trafficking
title Chitin Synthesis in Yeast: A Matter of Trafficking
title_full Chitin Synthesis in Yeast: A Matter of Trafficking
title_fullStr Chitin Synthesis in Yeast: A Matter of Trafficking
title_full_unstemmed Chitin Synthesis in Yeast: A Matter of Trafficking
title_short Chitin Synthesis in Yeast: A Matter of Trafficking
title_sort chitin synthesis in yeast: a matter of trafficking
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603707/
https://www.ncbi.nlm.nih.gov/pubmed/36293107
http://dx.doi.org/10.3390/ijms232012251
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