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Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment
Integrins are necessary for cell adhesion, migration, and positioning. Essential for inducing signalling events for cell survival, proliferation, and differentiation, they also trigger a variety of signal transduction pathways involved in mediating invasion, metastasis, and squamous-cell carcinoma....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603893/ https://www.ncbi.nlm.nih.gov/pubmed/36293202 http://dx.doi.org/10.3390/ijms232012346 |
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author | Brzozowska, Ewa Deshmukh, Sameer |
author_facet | Brzozowska, Ewa Deshmukh, Sameer |
author_sort | Brzozowska, Ewa |
collection | PubMed |
description | Integrins are necessary for cell adhesion, migration, and positioning. Essential for inducing signalling events for cell survival, proliferation, and differentiation, they also trigger a variety of signal transduction pathways involved in mediating invasion, metastasis, and squamous-cell carcinoma. Several recent studies have demonstrated that the up- and down-regulation of the expression of αv and other integrins can be a potent marker of malignant diseases and patient prognosis. This review focuses on an arginine-glycine-aspartic acid (RGD)-dependent integrin αVβ6, its biology, and its role in healthy humans. We examine the implications of αVβ6 in cancer progression and the promotion of epithelial-mesenchymal transition (EMT) by contributing to the activation of transforming growth factor beta TGF-β. Although αvβ6 is crucial for proper function in healthy people, it has also been validated as a target for cancer treatment. This review briefly considers aspects of targeting αVβ6 in the clinic via different therapeutic modalities. |
format | Online Article Text |
id | pubmed-9603893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96038932022-10-27 Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment Brzozowska, Ewa Deshmukh, Sameer Int J Mol Sci Review Integrins are necessary for cell adhesion, migration, and positioning. Essential for inducing signalling events for cell survival, proliferation, and differentiation, they also trigger a variety of signal transduction pathways involved in mediating invasion, metastasis, and squamous-cell carcinoma. Several recent studies have demonstrated that the up- and down-regulation of the expression of αv and other integrins can be a potent marker of malignant diseases and patient prognosis. This review focuses on an arginine-glycine-aspartic acid (RGD)-dependent integrin αVβ6, its biology, and its role in healthy humans. We examine the implications of αVβ6 in cancer progression and the promotion of epithelial-mesenchymal transition (EMT) by contributing to the activation of transforming growth factor beta TGF-β. Although αvβ6 is crucial for proper function in healthy people, it has also been validated as a target for cancer treatment. This review briefly considers aspects of targeting αVβ6 in the clinic via different therapeutic modalities. MDPI 2022-10-15 /pmc/articles/PMC9603893/ /pubmed/36293202 http://dx.doi.org/10.3390/ijms232012346 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Brzozowska, Ewa Deshmukh, Sameer Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment |
title | Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment |
title_full | Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment |
title_fullStr | Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment |
title_full_unstemmed | Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment |
title_short | Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment |
title_sort | integrin alpha v beta 6 (αvβ6) and its implications in cancer treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603893/ https://www.ncbi.nlm.nih.gov/pubmed/36293202 http://dx.doi.org/10.3390/ijms232012346 |
work_keys_str_mv | AT brzozowskaewa integrinalphavbeta6avb6anditsimplicationsincancertreatment AT deshmukhsameer integrinalphavbeta6avb6anditsimplicationsincancertreatment |