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Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment

Integrins are necessary for cell adhesion, migration, and positioning. Essential for inducing signalling events for cell survival, proliferation, and differentiation, they also trigger a variety of signal transduction pathways involved in mediating invasion, metastasis, and squamous-cell carcinoma....

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Detalles Bibliográficos
Autores principales: Brzozowska, Ewa, Deshmukh, Sameer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603893/
https://www.ncbi.nlm.nih.gov/pubmed/36293202
http://dx.doi.org/10.3390/ijms232012346
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author Brzozowska, Ewa
Deshmukh, Sameer
author_facet Brzozowska, Ewa
Deshmukh, Sameer
author_sort Brzozowska, Ewa
collection PubMed
description Integrins are necessary for cell adhesion, migration, and positioning. Essential for inducing signalling events for cell survival, proliferation, and differentiation, they also trigger a variety of signal transduction pathways involved in mediating invasion, metastasis, and squamous-cell carcinoma. Several recent studies have demonstrated that the up- and down-regulation of the expression of αv and other integrins can be a potent marker of malignant diseases and patient prognosis. This review focuses on an arginine-glycine-aspartic acid (RGD)-dependent integrin αVβ6, its biology, and its role in healthy humans. We examine the implications of αVβ6 in cancer progression and the promotion of epithelial-mesenchymal transition (EMT) by contributing to the activation of transforming growth factor beta TGF-β. Although αvβ6 is crucial for proper function in healthy people, it has also been validated as a target for cancer treatment. This review briefly considers aspects of targeting αVβ6 in the clinic via different therapeutic modalities.
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spelling pubmed-96038932022-10-27 Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment Brzozowska, Ewa Deshmukh, Sameer Int J Mol Sci Review Integrins are necessary for cell adhesion, migration, and positioning. Essential for inducing signalling events for cell survival, proliferation, and differentiation, they also trigger a variety of signal transduction pathways involved in mediating invasion, metastasis, and squamous-cell carcinoma. Several recent studies have demonstrated that the up- and down-regulation of the expression of αv and other integrins can be a potent marker of malignant diseases and patient prognosis. This review focuses on an arginine-glycine-aspartic acid (RGD)-dependent integrin αVβ6, its biology, and its role in healthy humans. We examine the implications of αVβ6 in cancer progression and the promotion of epithelial-mesenchymal transition (EMT) by contributing to the activation of transforming growth factor beta TGF-β. Although αvβ6 is crucial for proper function in healthy people, it has also been validated as a target for cancer treatment. This review briefly considers aspects of targeting αVβ6 in the clinic via different therapeutic modalities. MDPI 2022-10-15 /pmc/articles/PMC9603893/ /pubmed/36293202 http://dx.doi.org/10.3390/ijms232012346 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Brzozowska, Ewa
Deshmukh, Sameer
Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment
title Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment
title_full Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment
title_fullStr Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment
title_full_unstemmed Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment
title_short Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment
title_sort integrin alpha v beta 6 (αvβ6) and its implications in cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603893/
https://www.ncbi.nlm.nih.gov/pubmed/36293202
http://dx.doi.org/10.3390/ijms232012346
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