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Tissue Engineering in Gynecology
Female gynecological organ dysfunction can cause infertility and psychological distress, decreasing the quality of life of affected women. Incidence is constantly increasing due to growing rates of cancer and increase of childbearing age in the developed world. Current treatments are often unable to...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603941/ https://www.ncbi.nlm.nih.gov/pubmed/36293171 http://dx.doi.org/10.3390/ijms232012319 |
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author | Brownell, David Chabaud, Stéphane Bolduc, Stéphane |
author_facet | Brownell, David Chabaud, Stéphane Bolduc, Stéphane |
author_sort | Brownell, David |
collection | PubMed |
description | Female gynecological organ dysfunction can cause infertility and psychological distress, decreasing the quality of life of affected women. Incidence is constantly increasing due to growing rates of cancer and increase of childbearing age in the developed world. Current treatments are often unable to restore organ function, and occasionally are the cause of female infertility. Alternative treatment options are currently being developed in order to face the inadequacy of current practices. In this review, pathologies and current treatments of gynecological organs (ovaries, uterus, and vagina) are described. State-of-the-art of tissue engineering alternatives to common practices are evaluated with a focus on in vivo models. Tissue engineering is an ever-expanding field, integrating various domains of modern science to create sophisticated tissue substitutes in the hope of repairing or replacing dysfunctional organs using autologous cells. Its application to gynecology has the potential of restoring female fertility and sexual wellbeing. |
format | Online Article Text |
id | pubmed-9603941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96039412022-10-27 Tissue Engineering in Gynecology Brownell, David Chabaud, Stéphane Bolduc, Stéphane Int J Mol Sci Review Female gynecological organ dysfunction can cause infertility and psychological distress, decreasing the quality of life of affected women. Incidence is constantly increasing due to growing rates of cancer and increase of childbearing age in the developed world. Current treatments are often unable to restore organ function, and occasionally are the cause of female infertility. Alternative treatment options are currently being developed in order to face the inadequacy of current practices. In this review, pathologies and current treatments of gynecological organs (ovaries, uterus, and vagina) are described. State-of-the-art of tissue engineering alternatives to common practices are evaluated with a focus on in vivo models. Tissue engineering is an ever-expanding field, integrating various domains of modern science to create sophisticated tissue substitutes in the hope of repairing or replacing dysfunctional organs using autologous cells. Its application to gynecology has the potential of restoring female fertility and sexual wellbeing. MDPI 2022-10-14 /pmc/articles/PMC9603941/ /pubmed/36293171 http://dx.doi.org/10.3390/ijms232012319 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Brownell, David Chabaud, Stéphane Bolduc, Stéphane Tissue Engineering in Gynecology |
title | Tissue Engineering in Gynecology |
title_full | Tissue Engineering in Gynecology |
title_fullStr | Tissue Engineering in Gynecology |
title_full_unstemmed | Tissue Engineering in Gynecology |
title_short | Tissue Engineering in Gynecology |
title_sort | tissue engineering in gynecology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603941/ https://www.ncbi.nlm.nih.gov/pubmed/36293171 http://dx.doi.org/10.3390/ijms232012319 |
work_keys_str_mv | AT brownelldavid tissueengineeringingynecology AT chabaudstephane tissueengineeringingynecology AT bolducstephane tissueengineeringingynecology |