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Inhibiting Intestinal Krüppel-Like Factor 5 Impairs the Beneficial Role of Renal Denervation in Gut Microbiota in Rats with Heart Failure

Krüppel-like factor 5 (KLF5) is critical in maintaining intestinal barrier function, and renal denervation (RDN) mitigates gut microbiota aberrations in rats with heart failure (HF). It is unclear whether intestinal KLF5 can be regulated by RDN and whether inhibiting intestinal KLF5 weakens the bene...

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Detalles Bibliográficos
Autores principales: Guo, Zhiqin, Chen, Fuyan, Chen, Yufeng, Liu, Chao, Li, Shaonan, Chen, Pingan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603959/
https://www.ncbi.nlm.nih.gov/pubmed/36135378
http://dx.doi.org/10.1128/spectrum.02183-22