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The Implications of Noncoding RNAs in the Evolution and Progression of Nonalcoholic Fatty Liver Disease (NAFLD)-Related HCC

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver pathology worldwide. Meanwhile, liver cancer represents the sixth most common malignancy, with hepatocellular carcinoma (HCC) as the primary, most prevalent subtype. Due to the rising incidence of metabolic disorders, NAFLD has bec...

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Autores principales: Rusu, Ioana, Pirlog, Radu, Chiroi, Paul, Nutu, Andreea, Puia, Vlad Radu, Fetti, Alin Cornel, Rusu, Daniel Radu, Berindan-Neagoe, Ioana, Al Hajjar, Nadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603983/
https://www.ncbi.nlm.nih.gov/pubmed/36293225
http://dx.doi.org/10.3390/ijms232012370
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author Rusu, Ioana
Pirlog, Radu
Chiroi, Paul
Nutu, Andreea
Puia, Vlad Radu
Fetti, Alin Cornel
Rusu, Daniel Radu
Berindan-Neagoe, Ioana
Al Hajjar, Nadim
author_facet Rusu, Ioana
Pirlog, Radu
Chiroi, Paul
Nutu, Andreea
Puia, Vlad Radu
Fetti, Alin Cornel
Rusu, Daniel Radu
Berindan-Neagoe, Ioana
Al Hajjar, Nadim
author_sort Rusu, Ioana
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver pathology worldwide. Meanwhile, liver cancer represents the sixth most common malignancy, with hepatocellular carcinoma (HCC) as the primary, most prevalent subtype. Due to the rising incidence of metabolic disorders, NAFLD has become one of the main contributing factors to HCC development. However, although NAFLD might account for about a fourth of HCC cases, there is currently a significant gap in HCC surveillance protocols regarding noncirrhotic NAFLD patients, so the majority of NAFLD-related HCC cases were diagnosed in late stages when survival chances are minimal. However, in the past decade, the focus in cancer genomics has shifted towards the noncoding part of the genome, especially on the microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), which have proved to be involved in the regulation of several malignant processes. This review aims to summarize the current knowledge regarding some of the main dysregulated, noncoding RNAs (ncRNAs) and their implications for NAFLD and HCC development. A central focus of the review is on miRNA and lncRNAs that can influence the progression of NAFLD towards HCC and how they can be used as potential screening tools and future therapeutic targets.
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spelling pubmed-96039832022-10-27 The Implications of Noncoding RNAs in the Evolution and Progression of Nonalcoholic Fatty Liver Disease (NAFLD)-Related HCC Rusu, Ioana Pirlog, Radu Chiroi, Paul Nutu, Andreea Puia, Vlad Radu Fetti, Alin Cornel Rusu, Daniel Radu Berindan-Neagoe, Ioana Al Hajjar, Nadim Int J Mol Sci Review Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver pathology worldwide. Meanwhile, liver cancer represents the sixth most common malignancy, with hepatocellular carcinoma (HCC) as the primary, most prevalent subtype. Due to the rising incidence of metabolic disorders, NAFLD has become one of the main contributing factors to HCC development. However, although NAFLD might account for about a fourth of HCC cases, there is currently a significant gap in HCC surveillance protocols regarding noncirrhotic NAFLD patients, so the majority of NAFLD-related HCC cases were diagnosed in late stages when survival chances are minimal. However, in the past decade, the focus in cancer genomics has shifted towards the noncoding part of the genome, especially on the microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), which have proved to be involved in the regulation of several malignant processes. This review aims to summarize the current knowledge regarding some of the main dysregulated, noncoding RNAs (ncRNAs) and their implications for NAFLD and HCC development. A central focus of the review is on miRNA and lncRNAs that can influence the progression of NAFLD towards HCC and how they can be used as potential screening tools and future therapeutic targets. MDPI 2022-10-15 /pmc/articles/PMC9603983/ /pubmed/36293225 http://dx.doi.org/10.3390/ijms232012370 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rusu, Ioana
Pirlog, Radu
Chiroi, Paul
Nutu, Andreea
Puia, Vlad Radu
Fetti, Alin Cornel
Rusu, Daniel Radu
Berindan-Neagoe, Ioana
Al Hajjar, Nadim
The Implications of Noncoding RNAs in the Evolution and Progression of Nonalcoholic Fatty Liver Disease (NAFLD)-Related HCC
title The Implications of Noncoding RNAs in the Evolution and Progression of Nonalcoholic Fatty Liver Disease (NAFLD)-Related HCC
title_full The Implications of Noncoding RNAs in the Evolution and Progression of Nonalcoholic Fatty Liver Disease (NAFLD)-Related HCC
title_fullStr The Implications of Noncoding RNAs in the Evolution and Progression of Nonalcoholic Fatty Liver Disease (NAFLD)-Related HCC
title_full_unstemmed The Implications of Noncoding RNAs in the Evolution and Progression of Nonalcoholic Fatty Liver Disease (NAFLD)-Related HCC
title_short The Implications of Noncoding RNAs in the Evolution and Progression of Nonalcoholic Fatty Liver Disease (NAFLD)-Related HCC
title_sort implications of noncoding rnas in the evolution and progression of nonalcoholic fatty liver disease (nafld)-related hcc
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603983/
https://www.ncbi.nlm.nih.gov/pubmed/36293225
http://dx.doi.org/10.3390/ijms232012370
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