ATP8B1 Deficiency Results in Elevated Mitochondrial Phosphatidylethanolamine Levels and Increased Mitochondrial Oxidative Phosphorylation in Human Hepatoma Cells

ATP8B1 is a phospholipid flippase that is deficient in patients with progressive familial intrahepatic cholestasis type 1 (PFIC1). PFIC1 patients suffer from severe liver disease but also present with dyslipidemia, including low plasma cholesterol, of yet unknown etiology. Here we show that ATP8B1 k...

Descripción completa

Detalles Bibliográficos
Autores principales: Gómez-Mellado, Valentina E., Chang, Jung-Chin, Ho-Mok, Kam S., Bernardino Morcillo, Carmen, Kersten, Remco H. J., Oude Elferink, Ronald P. J., Verhoeven, Arthur J., Paulusma, Coen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604224/
https://www.ncbi.nlm.nih.gov/pubmed/36293199
http://dx.doi.org/10.3390/ijms232012344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604224/
https://www.ncbi.nlm.nih.gov/pubmed/36293199
http://dx.doi.org/10.3390/ijms232012344

Ejemplares similares