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Chronic Nodular Prurigo: An Update on the Pathogenesis and Treatment
Chronic nodular prurigo (CNPG) is a recalcitrant chronic itchy disorder that affects the quality of life. It can be triggered by multiple etiologies, such as atopic dermatitis, diabetes, and chronic renal diseases. The mechanisms of CNPG are complicated and involved the interaction of the cutaneous,...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604302/ https://www.ncbi.nlm.nih.gov/pubmed/36293248 http://dx.doi.org/10.3390/ijms232012390 |
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author | Wong, Lai-San Yen, Yu-Ta |
author_facet | Wong, Lai-San Yen, Yu-Ta |
author_sort | Wong, Lai-San |
collection | PubMed |
description | Chronic nodular prurigo (CNPG) is a recalcitrant chronic itchy disorder that affects the quality of life. It can be triggered by multiple etiologies, such as atopic dermatitis, diabetes, and chronic renal diseases. The mechanisms of CNPG are complicated and involved the interaction of the cutaneous, immune, and nervous systems. Diverse immune cells, including eosinophils, neutrophils, T cells, macrophages, and mast cells infiltrated the lesional skin of CNPG, which initiated the inflammatory cytokines and pruritogens release. In addition, the interaction between the immune cells and activated peripheral sensory nerve fibers by neurotransmitters caused neuroinflammation in the skin and intractable itch. This itch-scratch vicious cycle of CNPG results in disease exacerbation. CNPG is difficult to treat with traditional therapies. Recently, great advances have been made in the pathophysiology of both inflammation and pruritus transmission in CNPG. In this review, we summarize the updated mechanisms and novel therapies for CNPG. |
format | Online Article Text |
id | pubmed-9604302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96043022022-10-27 Chronic Nodular Prurigo: An Update on the Pathogenesis and Treatment Wong, Lai-San Yen, Yu-Ta Int J Mol Sci Review Chronic nodular prurigo (CNPG) is a recalcitrant chronic itchy disorder that affects the quality of life. It can be triggered by multiple etiologies, such as atopic dermatitis, diabetes, and chronic renal diseases. The mechanisms of CNPG are complicated and involved the interaction of the cutaneous, immune, and nervous systems. Diverse immune cells, including eosinophils, neutrophils, T cells, macrophages, and mast cells infiltrated the lesional skin of CNPG, which initiated the inflammatory cytokines and pruritogens release. In addition, the interaction between the immune cells and activated peripheral sensory nerve fibers by neurotransmitters caused neuroinflammation in the skin and intractable itch. This itch-scratch vicious cycle of CNPG results in disease exacerbation. CNPG is difficult to treat with traditional therapies. Recently, great advances have been made in the pathophysiology of both inflammation and pruritus transmission in CNPG. In this review, we summarize the updated mechanisms and novel therapies for CNPG. MDPI 2022-10-16 /pmc/articles/PMC9604302/ /pubmed/36293248 http://dx.doi.org/10.3390/ijms232012390 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wong, Lai-San Yen, Yu-Ta Chronic Nodular Prurigo: An Update on the Pathogenesis and Treatment |
title | Chronic Nodular Prurigo: An Update on the Pathogenesis and Treatment |
title_full | Chronic Nodular Prurigo: An Update on the Pathogenesis and Treatment |
title_fullStr | Chronic Nodular Prurigo: An Update on the Pathogenesis and Treatment |
title_full_unstemmed | Chronic Nodular Prurigo: An Update on the Pathogenesis and Treatment |
title_short | Chronic Nodular Prurigo: An Update on the Pathogenesis and Treatment |
title_sort | chronic nodular prurigo: an update on the pathogenesis and treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604302/ https://www.ncbi.nlm.nih.gov/pubmed/36293248 http://dx.doi.org/10.3390/ijms232012390 |
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