Cargando…

Echocardiographic Abnormalities in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients

Cardiovascular abnormalities, such as left ventricular hypertrophy and valvular disorders, particularly mitral valve prolapse, have been described as highly prevalent among adult patients with autosomal dominant polycystic kidney disease (ADPKD). The present study aimed to assess echocardiographic p...

Descripción completa

Detalles Bibliográficos
Autores principales: Pfeferman, Mariana Becker, da Rocha, Daniel Ribeiro, Rodrigues, Fernanda Guedes, Pfeferman, Elcio, Heilberg, Ita Pfeferman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604303/
https://www.ncbi.nlm.nih.gov/pubmed/36294302
http://dx.doi.org/10.3390/jcm11205982
_version_ 1784817779784810496
author Pfeferman, Mariana Becker
da Rocha, Daniel Ribeiro
Rodrigues, Fernanda Guedes
Pfeferman, Elcio
Heilberg, Ita Pfeferman
author_facet Pfeferman, Mariana Becker
da Rocha, Daniel Ribeiro
Rodrigues, Fernanda Guedes
Pfeferman, Elcio
Heilberg, Ita Pfeferman
author_sort Pfeferman, Mariana Becker
collection PubMed
description Cardiovascular abnormalities, such as left ventricular hypertrophy and valvular disorders, particularly mitral valve prolapse, have been described as highly prevalent among adult patients with autosomal dominant polycystic kidney disease (ADPKD). The present study aimed to assess echocardiographic parameters in a large sample of both normotensive and hypertensive ADPKD patients, regardless of kidney function level, and evaluate their association with clinical and laboratorial parameters. A retrospective study consisted of the analysis of clinical, laboratorial, and transthoracic echocardiograms data retrieved from the medical records of young adult ADPKD outpatients. A total of 294 patients (120 M/174 F, 41.0 ± 13.8 years old, 199 hypertensive and 95 normotensive) with a median estimated glomerular filtration rate (eGFR) of 75.5 mL/min/1.73 m(2) were included. The hypertensive group (67.6%) was significantly older and exhibited significantly lower eGFR than the normotensive one. Increased left ventricular mass index (LVMI) was seen in 2.0%, mitral valve prolapse was observed in 3.4%, mitral valve regurgitation in 15.3%, tricuspid valve regurgitation in 16.0%, and aortic valve regurgitation in 4.8% of the whole sample. The present study suggested that the prevalence of mitral valve prolapse was much lower than previously reported, and increased LVMI was not seen in most adult ADPKD patients.
format Online
Article
Text
id pubmed-9604303
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96043032022-10-27 Echocardiographic Abnormalities in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients Pfeferman, Mariana Becker da Rocha, Daniel Ribeiro Rodrigues, Fernanda Guedes Pfeferman, Elcio Heilberg, Ita Pfeferman J Clin Med Article Cardiovascular abnormalities, such as left ventricular hypertrophy and valvular disorders, particularly mitral valve prolapse, have been described as highly prevalent among adult patients with autosomal dominant polycystic kidney disease (ADPKD). The present study aimed to assess echocardiographic parameters in a large sample of both normotensive and hypertensive ADPKD patients, regardless of kidney function level, and evaluate their association with clinical and laboratorial parameters. A retrospective study consisted of the analysis of clinical, laboratorial, and transthoracic echocardiograms data retrieved from the medical records of young adult ADPKD outpatients. A total of 294 patients (120 M/174 F, 41.0 ± 13.8 years old, 199 hypertensive and 95 normotensive) with a median estimated glomerular filtration rate (eGFR) of 75.5 mL/min/1.73 m(2) were included. The hypertensive group (67.6%) was significantly older and exhibited significantly lower eGFR than the normotensive one. Increased left ventricular mass index (LVMI) was seen in 2.0%, mitral valve prolapse was observed in 3.4%, mitral valve regurgitation in 15.3%, tricuspid valve regurgitation in 16.0%, and aortic valve regurgitation in 4.8% of the whole sample. The present study suggested that the prevalence of mitral valve prolapse was much lower than previously reported, and increased LVMI was not seen in most adult ADPKD patients. MDPI 2022-10-11 /pmc/articles/PMC9604303/ /pubmed/36294302 http://dx.doi.org/10.3390/jcm11205982 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pfeferman, Mariana Becker
da Rocha, Daniel Ribeiro
Rodrigues, Fernanda Guedes
Pfeferman, Elcio
Heilberg, Ita Pfeferman
Echocardiographic Abnormalities in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients
title Echocardiographic Abnormalities in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients
title_full Echocardiographic Abnormalities in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients
title_fullStr Echocardiographic Abnormalities in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients
title_full_unstemmed Echocardiographic Abnormalities in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients
title_short Echocardiographic Abnormalities in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients
title_sort echocardiographic abnormalities in autosomal dominant polycystic kidney disease (adpkd) patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604303/
https://www.ncbi.nlm.nih.gov/pubmed/36294302
http://dx.doi.org/10.3390/jcm11205982
work_keys_str_mv AT pfefermanmarianabecker echocardiographicabnormalitiesinautosomaldominantpolycystickidneydiseaseadpkdpatients
AT darochadanielribeiro echocardiographicabnormalitiesinautosomaldominantpolycystickidneydiseaseadpkdpatients
AT rodriguesfernandaguedes echocardiographicabnormalitiesinautosomaldominantpolycystickidneydiseaseadpkdpatients
AT pfefermanelcio echocardiographicabnormalitiesinautosomaldominantpolycystickidneydiseaseadpkdpatients
AT heilbergitapfeferman echocardiographicabnormalitiesinautosomaldominantpolycystickidneydiseaseadpkdpatients