Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation

CYP2J2 is the main epoxygenase in the heart that is responsible for oxidizing arachidonic acid to cis-epoxyeicosatrienoic acids (EETs). Once formed, EETs can then be hydrolyzed by soluble epoxide hydrolase (sEH, encoded by EPHX2) or re-esterified back to the membrane. EETs have several cardioprotect...

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Detalles Bibliográficos
Autores principales: Aliwarga, Theresa, Dinh, Jean C., Heyward, Scott, Prasad, Bhagwat, Gharib, Sina A., Lemaitre, Rozenn N., Sotoodehnia, Nona, Totah, Rheem A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604309/
https://www.ncbi.nlm.nih.gov/pubmed/36293289
http://dx.doi.org/10.3390/ijms232012433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604309/
https://www.ncbi.nlm.nih.gov/pubmed/36293289
http://dx.doi.org/10.3390/ijms232012433

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