Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demonstration of an Intricate Mechanism

We report herein a novel mechanism, unraveled by proteomics and validated by in vitro and in vivo studies, of the aberrant aging-associated upregulation of ovarian transferrin and ferritin in rat ovaries. The ovarian mass and serum estradiol titer plummeted while the ovarian labile ferrous iron and...

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Detalles Bibliográficos
Autores principales: Sze, Stephen Cho Wing, Zhang, Liang, Zhang, Shiqing, Lin, Kaili, Ng, Tzi Bun, Ng, Man Ling, Lee, Kai-Fai, Lam, Jenny Ka Wing, Zhang, Zhang, Yung, Ken Kin Lam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604315/
https://www.ncbi.nlm.nih.gov/pubmed/36293552
http://dx.doi.org/10.3390/ijms232012689

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