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Role of Tunneling Nanotubes in the Nervous System

Cellular communication and the transfer of information from one cell to another is crucial for cell viability and homeostasis. During the last decade, tunneling nanotubes (TNTs) have attracted scientific attention, not only as a means of direct intercellular communication, but also as a possible sys...

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Detalles Bibliográficos
Autores principales: Tarasiuk, Olga, Scuteri, Arianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604327/
https://www.ncbi.nlm.nih.gov/pubmed/36293396
http://dx.doi.org/10.3390/ijms232012545
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author Tarasiuk, Olga
Scuteri, Arianna
author_facet Tarasiuk, Olga
Scuteri, Arianna
author_sort Tarasiuk, Olga
collection PubMed
description Cellular communication and the transfer of information from one cell to another is crucial for cell viability and homeostasis. During the last decade, tunneling nanotubes (TNTs) have attracted scientific attention, not only as a means of direct intercellular communication, but also as a possible system to transport biological cargo between distant cells. Peculiar TNT characteristics make them both able to increase cellular survival capacities, as well as a potential target of neurodegenerative disease progression. Despite TNT formation having been documented in a number of cell types, the exact mechanisms triggering their formation are still not completely known. In this review, we will summarize and highlight those studies focusing on TNT formation in the nervous system, as well as their role in neurodegenerative diseases. Moreover, we aim to stress some possible mechanisms and important proteins probably involved in TNT formation in the nervous system.
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spelling pubmed-96043272022-10-27 Role of Tunneling Nanotubes in the Nervous System Tarasiuk, Olga Scuteri, Arianna Int J Mol Sci Review Cellular communication and the transfer of information from one cell to another is crucial for cell viability and homeostasis. During the last decade, tunneling nanotubes (TNTs) have attracted scientific attention, not only as a means of direct intercellular communication, but also as a possible system to transport biological cargo between distant cells. Peculiar TNT characteristics make them both able to increase cellular survival capacities, as well as a potential target of neurodegenerative disease progression. Despite TNT formation having been documented in a number of cell types, the exact mechanisms triggering their formation are still not completely known. In this review, we will summarize and highlight those studies focusing on TNT formation in the nervous system, as well as their role in neurodegenerative diseases. Moreover, we aim to stress some possible mechanisms and important proteins probably involved in TNT formation in the nervous system. MDPI 2022-10-19 /pmc/articles/PMC9604327/ /pubmed/36293396 http://dx.doi.org/10.3390/ijms232012545 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tarasiuk, Olga
Scuteri, Arianna
Role of Tunneling Nanotubes in the Nervous System
title Role of Tunneling Nanotubes in the Nervous System
title_full Role of Tunneling Nanotubes in the Nervous System
title_fullStr Role of Tunneling Nanotubes in the Nervous System
title_full_unstemmed Role of Tunneling Nanotubes in the Nervous System
title_short Role of Tunneling Nanotubes in the Nervous System
title_sort role of tunneling nanotubes in the nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604327/
https://www.ncbi.nlm.nih.gov/pubmed/36293396
http://dx.doi.org/10.3390/ijms232012545
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