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Role of Tunneling Nanotubes in the Nervous System
Cellular communication and the transfer of information from one cell to another is crucial for cell viability and homeostasis. During the last decade, tunneling nanotubes (TNTs) have attracted scientific attention, not only as a means of direct intercellular communication, but also as a possible sys...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604327/ https://www.ncbi.nlm.nih.gov/pubmed/36293396 http://dx.doi.org/10.3390/ijms232012545 |
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author | Tarasiuk, Olga Scuteri, Arianna |
author_facet | Tarasiuk, Olga Scuteri, Arianna |
author_sort | Tarasiuk, Olga |
collection | PubMed |
description | Cellular communication and the transfer of information from one cell to another is crucial for cell viability and homeostasis. During the last decade, tunneling nanotubes (TNTs) have attracted scientific attention, not only as a means of direct intercellular communication, but also as a possible system to transport biological cargo between distant cells. Peculiar TNT characteristics make them both able to increase cellular survival capacities, as well as a potential target of neurodegenerative disease progression. Despite TNT formation having been documented in a number of cell types, the exact mechanisms triggering their formation are still not completely known. In this review, we will summarize and highlight those studies focusing on TNT formation in the nervous system, as well as their role in neurodegenerative diseases. Moreover, we aim to stress some possible mechanisms and important proteins probably involved in TNT formation in the nervous system. |
format | Online Article Text |
id | pubmed-9604327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96043272022-10-27 Role of Tunneling Nanotubes in the Nervous System Tarasiuk, Olga Scuteri, Arianna Int J Mol Sci Review Cellular communication and the transfer of information from one cell to another is crucial for cell viability and homeostasis. During the last decade, tunneling nanotubes (TNTs) have attracted scientific attention, not only as a means of direct intercellular communication, but also as a possible system to transport biological cargo between distant cells. Peculiar TNT characteristics make them both able to increase cellular survival capacities, as well as a potential target of neurodegenerative disease progression. Despite TNT formation having been documented in a number of cell types, the exact mechanisms triggering their formation are still not completely known. In this review, we will summarize and highlight those studies focusing on TNT formation in the nervous system, as well as their role in neurodegenerative diseases. Moreover, we aim to stress some possible mechanisms and important proteins probably involved in TNT formation in the nervous system. MDPI 2022-10-19 /pmc/articles/PMC9604327/ /pubmed/36293396 http://dx.doi.org/10.3390/ijms232012545 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tarasiuk, Olga Scuteri, Arianna Role of Tunneling Nanotubes in the Nervous System |
title | Role of Tunneling Nanotubes in the Nervous System |
title_full | Role of Tunneling Nanotubes in the Nervous System |
title_fullStr | Role of Tunneling Nanotubes in the Nervous System |
title_full_unstemmed | Role of Tunneling Nanotubes in the Nervous System |
title_short | Role of Tunneling Nanotubes in the Nervous System |
title_sort | role of tunneling nanotubes in the nervous system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604327/ https://www.ncbi.nlm.nih.gov/pubmed/36293396 http://dx.doi.org/10.3390/ijms232012545 |
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