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Advances in the Management of Central Nervous System Metastases from Breast Cancer

Central nervous system (CNS) metastases are common in breast cancer (BC) patients and are particularly relevant as new treatments for BC are prolonging survival. Here, we review advances in the treatment of CNS metastases from BC, including radiotherapy, systemic therapies, and the evolving role of...

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Detalles Bibliográficos
Autores principales: Avila, Jorge, Leone, José Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604332/
https://www.ncbi.nlm.nih.gov/pubmed/36293379
http://dx.doi.org/10.3390/ijms232012525
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author Avila, Jorge
Leone, José Pablo
author_facet Avila, Jorge
Leone, José Pablo
author_sort Avila, Jorge
collection PubMed
description Central nervous system (CNS) metastases are common in breast cancer (BC) patients and are particularly relevant as new treatments for BC are prolonging survival. Here, we review advances in the treatment of CNS metastases from BC, including radiotherapy, systemic therapies, and the evolving role of immunotherapy. The use of radiotherapy and chemotherapy is the cornerstone of treatment for CNS metastases. However, new targeted therapies have recently been developed, including anti-HER2 agents and antibody–drug conjugates that have presented promising results for the treatment of these patients.
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spelling pubmed-96043322022-10-27 Advances in the Management of Central Nervous System Metastases from Breast Cancer Avila, Jorge Leone, José Pablo Int J Mol Sci Review Central nervous system (CNS) metastases are common in breast cancer (BC) patients and are particularly relevant as new treatments for BC are prolonging survival. Here, we review advances in the treatment of CNS metastases from BC, including radiotherapy, systemic therapies, and the evolving role of immunotherapy. The use of radiotherapy and chemotherapy is the cornerstone of treatment for CNS metastases. However, new targeted therapies have recently been developed, including anti-HER2 agents and antibody–drug conjugates that have presented promising results for the treatment of these patients. MDPI 2022-10-19 /pmc/articles/PMC9604332/ /pubmed/36293379 http://dx.doi.org/10.3390/ijms232012525 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Avila, Jorge
Leone, José Pablo
Advances in the Management of Central Nervous System Metastases from Breast Cancer
title Advances in the Management of Central Nervous System Metastases from Breast Cancer
title_full Advances in the Management of Central Nervous System Metastases from Breast Cancer
title_fullStr Advances in the Management of Central Nervous System Metastases from Breast Cancer
title_full_unstemmed Advances in the Management of Central Nervous System Metastases from Breast Cancer
title_short Advances in the Management of Central Nervous System Metastases from Breast Cancer
title_sort advances in the management of central nervous system metastases from breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604332/
https://www.ncbi.nlm.nih.gov/pubmed/36293379
http://dx.doi.org/10.3390/ijms232012525
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