Truncated Analogues of a G-Quadruplex-Forming Aptamer Targeting Mutant Huntingtin: Shorter Is Better!

Two analogues of the MS3 aptamer, which was previously shown to have an exquisite capability to selectively bind and modulate the activity of mutant huntingtin (mHTT), have been here designed and evaluated in their physicochemical and biological properties. Featured by a distinctive propensity to fo...

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Detalles Bibliográficos
Autores principales: Riccardi, Claudia, D’Aria, Federica, Fasano, Dominga, Digilio, Filomena Anna, Carillo, Maria Rosaria, Amato, Jussara, De Rosa, Laura, Paladino, Simona, Melone, Mariarosa Anna Beatrice, Montesarchio, Daniela, Giancola, Concetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604342/
https://www.ncbi.nlm.nih.gov/pubmed/36293267
http://dx.doi.org/10.3390/ijms232012412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604342/
https://www.ncbi.nlm.nih.gov/pubmed/36293267
http://dx.doi.org/10.3390/ijms232012412

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