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Transport in the Brain Extracellular Space: Diffusion, but Which Kind?

The mechanisms of transport of substances in the brain parenchyma have been a hot topic in scientific discussion in the past decade. This discussion was triggered by the proposed glymphatic hypothesis, which assumes a directed flow of cerebral fluid within the parenchyma, in contrast to the previous...

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Detalles Bibliográficos
Autores principales: Postnikov, Eugene B., Lavrova, Anastasia I., Postnov, Dmitry E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604357/
https://www.ncbi.nlm.nih.gov/pubmed/36293258
http://dx.doi.org/10.3390/ijms232012401
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author Postnikov, Eugene B.
Lavrova, Anastasia I.
Postnov, Dmitry E.
author_facet Postnikov, Eugene B.
Lavrova, Anastasia I.
Postnov, Dmitry E.
author_sort Postnikov, Eugene B.
collection PubMed
description The mechanisms of transport of substances in the brain parenchyma have been a hot topic in scientific discussion in the past decade. This discussion was triggered by the proposed glymphatic hypothesis, which assumes a directed flow of cerebral fluid within the parenchyma, in contrast to the previous notion that diffusion is the main mechanism. However, when discussing the issue of “diffusion or non-diffusion”, much less attention was given to the question that diffusion itself can have a different character. In our opinion, some of the recently published results do not fit into the traditional understanding of diffusion. In this regard, we outline the relevant new theoretical approaches on transport processes in complex random media such as concepts of diffusive diffusivity and time-dependent homogenization, which expands the understanding of the forms of transport of substances based on diffusion.
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spelling pubmed-96043572022-10-27 Transport in the Brain Extracellular Space: Diffusion, but Which Kind? Postnikov, Eugene B. Lavrova, Anastasia I. Postnov, Dmitry E. Int J Mol Sci Review The mechanisms of transport of substances in the brain parenchyma have been a hot topic in scientific discussion in the past decade. This discussion was triggered by the proposed glymphatic hypothesis, which assumes a directed flow of cerebral fluid within the parenchyma, in contrast to the previous notion that diffusion is the main mechanism. However, when discussing the issue of “diffusion or non-diffusion”, much less attention was given to the question that diffusion itself can have a different character. In our opinion, some of the recently published results do not fit into the traditional understanding of diffusion. In this regard, we outline the relevant new theoretical approaches on transport processes in complex random media such as concepts of diffusive diffusivity and time-dependent homogenization, which expands the understanding of the forms of transport of substances based on diffusion. MDPI 2022-10-17 /pmc/articles/PMC9604357/ /pubmed/36293258 http://dx.doi.org/10.3390/ijms232012401 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Postnikov, Eugene B.
Lavrova, Anastasia I.
Postnov, Dmitry E.
Transport in the Brain Extracellular Space: Diffusion, but Which Kind?
title Transport in the Brain Extracellular Space: Diffusion, but Which Kind?
title_full Transport in the Brain Extracellular Space: Diffusion, but Which Kind?
title_fullStr Transport in the Brain Extracellular Space: Diffusion, but Which Kind?
title_full_unstemmed Transport in the Brain Extracellular Space: Diffusion, but Which Kind?
title_short Transport in the Brain Extracellular Space: Diffusion, but Which Kind?
title_sort transport in the brain extracellular space: diffusion, but which kind?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604357/
https://www.ncbi.nlm.nih.gov/pubmed/36293258
http://dx.doi.org/10.3390/ijms232012401
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