The PSI Domain of the MET Oncogene Encodes a Functional Disulfide Isomerase Essential for the Maturation of the Receptor Precursor

The tyrosine kinase receptor encoded by the MET oncogene has been extensively studied. Surprisingly, one extracellular domain, PSI, evolutionary conserved between plexins, semaphorins, and integrins, has no established function. The MET PSI sequence contains two CXXC motifs, usually found in protein...

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Detalles Bibliográficos
Autores principales: Altintas, Dogus Murat, Gallo, Simona, Basilico, Cristina, Cerqua, Marina, Bocedi, Alessio, Vitacolonna, Annapia, Botti, Orsola, Casanova, Elena, Rancati, Ilaria, Milanese, Chiara, Notari, Sara, Gambardella, Giorgia, Ricci, Giorgio, Mastroberardino, Pier Giorgio, Boccaccio, Carla, Crepaldi, Tiziana, Comoglio, Paolo Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604360/
https://www.ncbi.nlm.nih.gov/pubmed/36293286
http://dx.doi.org/10.3390/ijms232012427

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